2-deoxy-2-fluoro-3,4,6,7-tetra-O-TBDMS-6-D-glycero-β-1-(dibenzyphosphoryl)-D-hepto-glucopyranoside | 888487-40-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-deoxy-2-fluoro-3,4,6,7-tetra-O-TBDMS-6-D-glycero-β-1-(dibenzyphosphoryl)-D-hepto-glucopyranoside
• CAS: 888487-40-9
• 化学式: C₄₅H₈₂FO₉PSi₄
• 分子量: 929.455
• InChiKey: VQWLBIPIHUXGJA-CPUWOCMISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.8
• 重原子数：
  60.0
• 可旋转键数：
  18.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  90.91
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  2-deoxy-2-fluoro-3,4,6,7-tetra-O-TBDMS-6-D-glycero-β-1-(dibenzyphosphoryl)-D-hepto-glucopyranoside 在 palladium on activated charcoal 、 氢气 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 生成
  参考文献：
  名称：

  β-Selective One-Pot Fluorophosphorylation ofd,d-Heptosylglycals Mediated by Selectfluor

  摘要：

  AbstractThis study describes the development of a novel procedure of glycal fluorophosphorylation applied to the synthesis of a fluorinated analogue of an important bacterial metabolite. This procedure was applied to several heptose‐derived glycals, and the stereochemical outcome of the reaction was analyzed. Under optimized conditions, the reaction is β‐gluco selective, but a significant amount of the α‐gluco diastereomer is also generated.

  DOI：

  10.1002/ijch.201400148
• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 在 15-冠醚-5 、 硝基甲烷 、 sodium 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 2-deoxy-2-fluoro-3,4,6,7-tetra-O-TBDMS-6-D-glycero-β-1-(dibenzyphosphoryl)-D-hepto-glucopyranoside 、
  参考文献：
  名称：

  β-Selective One-Pot Fluorophosphorylation ofd,d-Heptosylglycals Mediated by Selectfluor

  摘要：

  AbstractThis study describes the development of a novel procedure of glycal fluorophosphorylation applied to the synthesis of a fluorinated analogue of an important bacterial metabolite. This procedure was applied to several heptose‐derived glycals, and the stereochemical outcome of the reaction was analyzed. Under optimized conditions, the reaction is β‐gluco selective, but a significant amount of the α‐gluco diastereomer is also generated.

  DOI：

  10.1002/ijch.201400148

文献信息

• WO2006/58796
  申请人：——

  公开号：——

  公开（公告）日：——