2,6-difluoro-4-(3-((2-methylquinolin-6-yl)methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)benzoic acid | 1459730-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,6-difluoro-4-(3-((2-methylquinolin-6-yl)methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)benzoic acid
• 英文别名: 2,6-Difluoro-4-[3-[(2-methylquinolin-6-yl)methyl]triazolo[4,5-b]pyridin-5-yl]benzoic acid
• CAS: 1459730-68-7
• 化学式: C₂₃H₁₅F₂N₅O₂
• 分子量: 431.401
• InChiKey: PYVDDZPMFQCQAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  93.8
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  methyl 2,6-difluoro-4-(3-((2-methylquinolin-6-yl)methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)benzoate 在 水 、 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 12.0h， 以51%的产率得到2,6-difluoro-4-(3-((2-methylquinolin-6-yl)methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)benzoic acid
  参考文献：
  名称：

  NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN, ETC

  摘要：

  本发明提供了作为c-Met蛋白激酶调节剂有用的化合物，以及制备它们的方法，含有它们的药物组合物，以及使用它们进行治疗、预防和/或改善c-Met激酶介导的疾病或疾病的方法。

  公开号：

  US20150057309A1

文献信息

• 3,5-disubstituted-3H-imidazo[4,5-b]pyridine and 3,5-disubstituted-3H-[1,2,3]triazolo[4,5-B] pyridine compounds as modulators of c-Met protein kinases
  申请人：Rhizen Pharmaceuticals SA

  公开号：US11066402B2

  公开（公告）日：2021-07-20

  The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of c-Met kinase mediated disease or disorders with them.

  本发明提供了可用作 c-Met 蛋白激酶调节剂的化合物、制备它们的方法、含有它们的药物组合物以及用它们治疗、预防和/或改善 c-Met 激酶介导的疾病或紊乱的方法。
• [EN] NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES<br/>[FR] NOUVEAUX COMPOSÉS 3,5-DISUBSTITUÉS-3H-IMIDAZO[4,5-B]PYRIDINES ET 3,5-DISUBSTITUÉS-3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINES EN TANT QUE MODULATEURS DES PROTÉINES KINASES C-MET
  申请人：RHIZEN PHARMACEUTICALS SA

  公开号：WO2013144737A3

  公开（公告）日：2013-12-05
• NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES
  申请人：Rhizen Pharmaceuticals S.A.

  公开号：EP2831073A2

  公开（公告）日：2015-02-04
• NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5-DISUBSTITUTED-3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES
  申请人：Rhizen Pharmaceuticals SA

  公开号：US20180072721A1

  公开（公告）日：2018-03-15

  The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of c-Met kinase mediated disease or disorders with them.
• NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES
  申请人：Rhizen Pharmaceuticals SA

  公开号：US20210371416A1

  公开（公告）日：2021-12-02

  The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of c-Met kinase mediated disease or disorders with them.