2-isopropyl-6-methoxy-8-nitroquinoline | 685092-51-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-isopropyl-6-methoxy-8-nitroquinoline
• 英文别名: 6-methoxy-8-nitro-2-propan-2-ylquinoline
• CAS: 685092-51-7
• 化学式: C₁₃H₁₄N₂O₃
• 分子量: 246.266
• InChiKey: WSWVDXZZRPIJBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.28
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  65.26
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-isopropyl-6-methoxy-8-nitroquinoline 在 镍 氢气 、 三乙胺 作用下， 以 乙醇 为溶剂， 120.0 ℃ 、310.26 kPa 条件下， 反应 24.75h， 生成 2-[4-(2-isopropyl-6-methoxy-8-quinolinamino)pentyl]-1,3-isoindolinedione
  参考文献：
  名称：

  Synthesis and blood-schizontocidal antimalarial activities of 2-substituted/2,5-disubstituted-8-quinolinamines and some of their amino acid conjugates

  摘要：

  Thirteen new analogues (32-40, 45-48) of recently discovered potent blood-schizontocidal antimalarial agent, 2-tertbutylprimaquine (2) are synthesized and evaluated for in vivo antimalarial activities against drug-sensitive P. berghei strain and multi-drug resistant P. yoelii nigeriensis strain. Two of the amino acid conjugates (47-48) have exhibited potent antimalarial activities similar to that of 2 against both drug-sensitive and multi-drug resistant strains. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.12.029
• 作为产物：
  描述：

  6-甲氧基-8-硝基喹啉 、 异丁酸 在 ammonium peroxydisulfate 、 硫酸 、 silver nitrate 作用下， 以 水 、 乙腈 为溶剂， 反应 0.17h， 以47%的产率得到2-isopropyl-6-methoxy-8-nitroquinoline
  参考文献：
  名称：

  Synthesis and blood-schizontocidal antimalarial activities of 2-substituted/2,5-disubstituted-8-quinolinamines and some of their amino acid conjugates

  摘要：

  Thirteen new analogues (32-40, 45-48) of recently discovered potent blood-schizontocidal antimalarial agent, 2-tertbutylprimaquine (2) are synthesized and evaluated for in vivo antimalarial activities against drug-sensitive P. berghei strain and multi-drug resistant P. yoelii nigeriensis strain. Two of the amino acid conjugates (47-48) have exhibited potent antimalarial activities similar to that of 2 against both drug-sensitive and multi-drug resistant strains. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.12.029