| 1325230-71-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1325230-71-4
• 化学式: C₂₀H₂₂O
• 分子量: 278.394
• InChiKey: ZVGJZTZXXFVQMI-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  正丁基锂 、 邻溴苯甲醛 、 2-苯基-1-丙烯 在 palladium diacetate 、 N,N-二异丙基乙胺 、 三(邻甲基苯基)磷 作用下， 以 N,N-二甲基乙酰胺 、 四氢呋喃 为溶剂， 反应 12.0h， 生成 (Z)-1-(2-(2-phenylprop-1-enyl)phenyl)pentan-1-one 、 (E)-1-(2-(2-phenylprop-1-enyl)phenyl)pentan-1-one 、
  参考文献：
  名称：

  Cyclization Reaction for the Synthesis of Polysubstituted Naphthalenes in the Presence of Au(I) Precatalysts

  摘要：

  Au(I)-catalyzed cyclization of alkenyl carbonyl compounds leading to a variety of substituted naphthalenes has been developed. This process exploits a dual function of the Au(I) catalyst: (1) the oxophilic nature of the Au(I) catalyst, counterintuitive to the pi-acidic reactivities generally associated with Au catalysts, and (2) olefin isomerization supported by the outcome of isotope scrambling experiments. It cannot be completely excluded that TfOH is a true operative catalyst in this protocol. In view of the practicality, the unnecessity of isomerically pure starting material in this reaction is particularly attractive and valuable.

  DOI：

  10.1021/jo201339z