5-(piperidin-1-yl)quinoline | 1605-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-(piperidin-1-yl)quinoline
• 英文别名: 5-Piperidino-chinolin；5-(1-Piperidinyl)quinoline；5-piperidin-1-ylquinoline
• CAS: 1605-49-8
• 化学式: C₁₄H₁₆N₂
• 分子量: 212.294
• InChiKey: QTDOPSHHOSDURU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.23
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  16.13
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  哌啶 、 5-溴喹啉 在 tris(dibenzylideneacetone)dipalladium (0) (S)-N,N-dimethyl-1-[(R)-2-(diphenylphosphino)-ferrocenyl]ethylamine 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 0.17h， 以63%的产率得到5-(piperidin-1-yl)quinoline
  参考文献：
  名称：

  Palladium-Catalyzed Microwave-Assisted Amination of 1-Bromonaphthalenes and 5- and 8-Bromoquinolines

  摘要：

  1-Aminonaphthalenes and 5- and 8-aminoquinolines were rapidly prepared from the respective aryl bromides in good yields by Pd-catalyzed aryl amination under microwave conditions. Consistent improvements in yields over those obtained under standard conditions were seen with quinoline substrates. In the cases where 5-bromo-8-cyanoquinoline was used as a substrate, no desired products were obtained under standard conditions with a number of different primary and secondary amines. However, microwave conditions provided the desired products in good to excellent yields.

  DOI：

  10.1021/ol034072h