| 1262658-55-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1262658-55-8
• 化学式: C₈₅H₈₆N₂O₁₈Si
• 分子量: 1451.71
• InChiKey: ZXEOETXPGUXOGJ-QEEOSURVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.74
• 重原子数：
  106.0
• 可旋转键数：
  28.0
• 环数：
  14.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  236.98
• 氢给体数：
  3.0
• 氢受体数：
  18.0

反应信息

• 作为反应物：
  描述：

  、 ethyl 2-O-benzoyl-3,4,6-tri-O-benzyl-1-thio-α-D-mannopyranoside 在 N-碘代丁二酰亚胺 、 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 以76%的产率得到
  参考文献：
  名称：

  Encouraging Progress in the ω-Aspartylation of Complex Oligosaccharides as a General Route to β-N-Linked Glycopolypeptides

  摘要：

  Described herein is a method for the joining of complex peptides to complex oligosaccharides via an N-linkage. The omega-aspartylation is conducted by coupling fully deprotected glycosylamine with a peptide containing a unique thioacid at the omega-aspartate carboxyl. In the presence of HOBT, under conditions that, in principle, allow for oxidation, complex components are combined in encouraging yields to produce structurally and stereochemically defined N-linked glycopolypeptides wherein the carbohydrate domain can be quite complex. Various mechanisms for oxidative coupling are proposed.

  DOI：

  10.1021/ja110115a
• 作为产物：
  描述：

  在 三氟乙酸 、 乙硫醇 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以72%的产率得到
  参考文献：
  名称：

  Encouraging Progress in the ω-Aspartylation of Complex Oligosaccharides as a General Route to β-N-Linked Glycopolypeptides

  摘要：

  Described herein is a method for the joining of complex peptides to complex oligosaccharides via an N-linkage. The omega-aspartylation is conducted by coupling fully deprotected glycosylamine with a peptide containing a unique thioacid at the omega-aspartate carboxyl. In the presence of HOBT, under conditions that, in principle, allow for oxidation, complex components are combined in encouraging yields to produce structurally and stereochemically defined N-linked glycopolypeptides wherein the carbohydrate domain can be quite complex. Various mechanisms for oxidative coupling are proposed.

  DOI：

  10.1021/ja110115a