3-hydroxy-4-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-benzaldehyde | 952141-39-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-hydroxy-4-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-benzaldehyde
• 英文别名: 3-Hydroxy-4-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]benzaldehyde
• CAS: 952141-39-8
• 化学式: C₁₃H₁₈O₆
• 分子量: 270.282
• InChiKey: GDRKIXVOMNUQTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-hydroxy-4-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-benzaldehyde 、 乙酰乙酸乙酯 、 硫脲 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 96.0h， 以91%的产率得到ethyl 4-[3-hydroxy-4-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]phenyl]-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
  参考文献：
  名称：

  New chemical tools for investigating human mitotic kinesin Eg5

  摘要：

  We have designed and synthesized a series of monastrol derivatives, an allosteric inhibitor of Eg5, a motor protein responsible for the formation and maintenance of the bipolar spindle in mitotic cells. Sterically demanding structural modifications have been introduced on the skeleton of the parent drug either via a multicomponent Biginelli reaction or a stepwise modification of monastrol. The ability of these compounds to inhibit Eg5 activity has been investigated using two in vitro steady-state ATPase assays (basal and microtubule-stimulated) as well as a cell-based assay. One compound in the series appeared more potent than monastrol by a fivefold factor. Three other compounds that were unable to inhibit Eg5 ATPase activity in vitro proved potent Eg5 inhibitors in the cell-based assay. The results obtained led to the identification of structure-activity relationships further used to design an affinity matrix that can be used for fast and efficient purification of Eg5 from crude lysate of eukaryotic cells. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.06.016
• 作为产物：
  描述：

  2-氯乙氧基-2-乙氧基二乙醇 、 3,4-二羟基苯甲醛 在 potassium carbonate 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 以52%的产率得到3-hydroxy-4-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-benzaldehyde
  参考文献：
  名称：

  New chemical tools for investigating human mitotic kinesin Eg5

  摘要：

  We have designed and synthesized a series of monastrol derivatives, an allosteric inhibitor of Eg5, a motor protein responsible for the formation and maintenance of the bipolar spindle in mitotic cells. Sterically demanding structural modifications have been introduced on the skeleton of the parent drug either via a multicomponent Biginelli reaction or a stepwise modification of monastrol. The ability of these compounds to inhibit Eg5 activity has been investigated using two in vitro steady-state ATPase assays (basal and microtubule-stimulated) as well as a cell-based assay. One compound in the series appeared more potent than monastrol by a fivefold factor. Three other compounds that were unable to inhibit Eg5 ATPase activity in vitro proved potent Eg5 inhibitors in the cell-based assay. The results obtained led to the identification of structure-activity relationships further used to design an affinity matrix that can be used for fast and efficient purification of Eg5 from crude lysate of eukaryotic cells. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.06.016