磷酸红霉素 | 4501-00-2

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 磷酸红霉素
• 中文别名: 磷酸红阿奇霉素(红霉素)
• 英文名称: Erythromycin Phosphate
• 英文别名: (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;phosphoric acid
• CAS: 4501-00-2
• 化学式: C37H70NO17P
• 分子量: 831.9
• InChiKey: VUEMAFLGEMYXIH-YZPBMOCRSA-N

物化性质

• 熔点：
  145 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.86
• 重原子数：
  56
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  272
• 氢给体数：
  8
• 氢受体数：
  18

文献信息

• Oriented P4HB implants containing antimicrobial agents
  申请人：Tepha, Inc.

  公开号：US10874771B2

  公开（公告）日：2020-12-29

  Oriented resorbable implants made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof, have been developed that contain one or more antimicrobial agents to prevent colonization of the implants, and reduce or prevent the occurrence of infection following implantation in a patient. These oriented implants are particularly suitable for use in procedures where prolonged strength retention is necessary and there is a risk of infection. Coverings and receptacles made from poly-4-hydroxybutyrate and copolymers thereof, containing antimicrobial agents, have also been developed for use with implantable devices to prevent colonization of these devices, and to reduce or prevent the occurrence of infection following implantation of these devices in a patient. These coverings and receptacles may be used to hold, or partially or fully cover, devices such as pacemakers and neurostimulators. Preferably, the coverings and receptacles are made from meshes, non-wovens, films, fibers, and foams, and contain rifampin and minocycline.

  由聚-4-羟基丁酸酯（P4HB）及其共聚物制成的定向可吸收植入物已经研制成功，这种植入物含有一种或多种抗菌剂，可防止植入物的定植，减少或防止植入病人体内后发生感染。这些定向植入物尤其适用于需要长时间保持强度且有感染风险的手术。由聚-4-羟基丁酸及其共聚物制成的、含有抗菌剂的覆盖物和容器也已开发出来，可与植入式装置一起使用，以防止这些装置发生定植，并减少或防止病人植入这些装置后发生感染。这些覆盖物和容器可用于固定、部分或全部覆盖心脏起搏器和神经刺激器等装置。这些覆盖物和容器最好由网格布、无纺布、薄膜、纤维和泡沫制成，并含有利福平和米诺环素。
• DERMAL DELIVERY DEVICE WITH ULTRASONIC WELD
  申请人：Agile Therapeutics, Inc.

  公开号：EP2167001A1

  公开（公告）日：2010-03-31
• DERMAL DELIVERY DEVICE WITH IN SITU SEAL
  申请人：Agile Therapeutics, Inc.

  公开号：EP2167002A1

  公开（公告）日：2010-03-31
• ENHANCED RETENTION CAPABILITIES THROUGH METHODS COMPRISING SURFACE TREATMENT OF FUNCTIONAL PARTICULATE CARRIER MATERIALS, AND FUNCTIONAL PARTICULATE CARRIER MATERIALS MADE THEREFROM
  申请人：World Minerals, Inc.

  公开号：EP2207416A1

  公开（公告）日：2010-07-21
• COMPOSITIONS FOR TOPICAL APPLICATION OF COMPOUNDS
  申请人：Illustris Pharmaceuticals, Inc.

  公开号：EP3442488A1

  公开（公告）日：2019-02-20