4-amino-1,1-bis(hydroxymethyl) cyclohexane | 194023-45-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-amino-1,1-bis(hydroxymethyl) cyclohexane
• 英文别名: [4-Amino-1-(hydroxymethyl)cyclohexyl]methanol
• CAS: 194023-45-5
• 化学式: C₈H₁₇NO₂
• 分子量: 159.228
• InChiKey: BQLNDBGHJIRLJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-amino-1,1-bis(hydroxymethyl) cyclohexane 在 TEA 作用下， 以 吡啶 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Novel non-nucleosidic phosphoramidites for oligonucleotide modification and labeling

  摘要：

  A series of novel labeled phosphoramidites and CPG supports 1a-f with a new non-nucleosidic backbone based upon cyclohexyl-4-amino-1,1-dimethanol have been synthesized. These reagents have been used to label oligonucleotides with biotin and fluorescein at the 5'-, the 3'-, and internal positions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00278-3
• 作为产物：
  描述：

  在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 4-amino-1,1-bis(hydroxymethyl) cyclohexane
  参考文献：
  名称：

  Novel non-nucleosidic phosphoramidites for oligonucleotide modification and labeling

  摘要：

  A series of novel labeled phosphoramidites and CPG supports 1a-f with a new non-nucleosidic backbone based upon cyclohexyl-4-amino-1,1-dimethanol have been synthesized. These reagents have been used to label oligonucleotides with biotin and fluorescein at the 5'-, the 3'-, and internal positions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00278-3

文献信息

• NON-NUCLEOTIDE LINKING REAGENTS
  申请人：Biogenex Laboratories

  公开号：EP0954606B1

  公开（公告）日：2003-10-15
• DISPIROPYRROLIDINE DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2684880B1

  公开（公告）日：2018-02-28
• DISPIROPYRROLIDINE DERIVATIVES
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20220106324A1

  公开（公告）日：2022-04-07

  A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R 1 , R 2 , R 3 , ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
• US6130323A
  申请人：——

  公开号：US6130323A

  公开（公告）日：2000-10-10