2-methyl-1-(4-nitrophenyl)-4,5-diphenyl-1H-imidazole | 1444698-99-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-methyl-1-(4-nitrophenyl)-4,5-diphenyl-1H-imidazole
• CAS: 1444698-99-0
• 化学式: C₂₂H₁₇N₃O₂
• 分子量: 355.396
• InChiKey: GMRNATCRZFZNOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.42
• 重原子数：
  27.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  60.96
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  乙醛 、 4-硝基苯胺 、 联苯甲酰 在 ammonium acetate 作用下， 以 neat (no solvent) 为溶剂， 反应 2.5h， 以76%的产率得到2-methyl-1-(4-nitrophenyl)-4,5-diphenyl-1H-imidazole
  参考文献：
  名称：

  Clay supported titanium catalyst for the solvent free synthesis of tetrasubstituted imidazoles and benzimidazoles

  摘要：

  A series of clay supported metal containing catalysts were prepared and their catalytic performance was evaluated in the synthesis of tetrasubstitued imidazoles under solvent free condition. It was found that K10 supported titanium catalyst showed higher activity compared to other catalysts. The catalysts were characterized by FTIR, XRD, TG/DTA, BET surface area and SEM. The general applicability of the method was demonstrated for the synthesis of tetra- substituted imidazoles from aldehydes and amines containing various electron donating and electron withdrawing substituents. The diversity of the catalyst was studied by synthesis of benzimidazoles and quinoxalines. The mechanism of formation of the products is explained in detail. The catalyst was found to be active for three cycles. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2013.04.004