2-(difluoromethoxy)decane | 1333375-78-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(difluoromethoxy)decane
• CAS: 1333375-78-2
• 化学式: C₁₁H₂₂F₂O
• 分子量: 208.292
• InChiKey: RAOSXPAJJFMOKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.36
• 重原子数：
  14.0
• 可旋转键数：
  9.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  2-癸醇 、 N,N-dimethyl-S-difluoromethyl-S-phenylsulfoximinium tetrafluoroborate 以 二氯甲烷 为溶剂， 反应 1.0h， 以37%的产率得到2-(difluoromethoxy)decane
  参考文献：
  名称：

  N,N-Dimethyl-S-difluoromethyl-S-phenylsulfoximinium tetrafluoroborate: A versatile electrophilic difluoromethylating reagent

  摘要：

  Over the past decade, sulfur-based fluoromethyl containing compounds have been exhaustively investigated as versatile fluoroalkylating reagents by our research laboratory as well as many others. Lately, we have designed a novel electrophilic difluoromethylating protocol employing in situ prepared N,N-dimethyl-S-difluoromethyl-S-phenylsulfoximinium salt. The present reagent provides excellent reactivity toward a broad spectrum of nucleophilic species (N-, P-, S-, and O-nucleophiles) to yield the corresponding difluoromethylated products with high efficacy under mild conditions. Additional studies have been performed to elucidate the mechanistic fundamentals of the reactions. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2011.04.023