3-甲氧基-2-(甲氧基甲基)-1-苯基-1-丙酮 | 100257-34-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-甲氧基-2-(甲氧基甲基)-1-苯基-1-丙酮
• 英文名称: 3-methoxy-2-(methoxymethyl)-1-phenylpropan-1-one
• 英文别名: 3-Methoxy-2-(methoxymethyl)-1-phenyl-1-propanone
• CAS: 100257-34-9
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: VNHVZUOJXIEJPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-甲氧基-2-(甲氧基甲基)-1-苯基-1-丙酮 在 氢溴酸 作用下， 反应 24.0h， 生成 1,3-Dibromo-2-benzoylpropane
  参考文献：
  名称：

  Mobile keto allyl systems. 18. Synthesis and chemistry of N-substituted and N,N-disubstituted 2-benzoyl-1-amino-3-propenes

  摘要：

  DOI：

  10.1021/jo01312a034
• 作为产物：
  描述：

  苯乙酮 在 potassium carbonate 、 paraformaldehyde 作用下， 以 甲醇 为溶剂， 生成 3-甲氧基-2-(甲氧基甲基)-1-苯基-1-丙酮
  参考文献：
  名称：

  Process and composition for inhibiting iron and steel corrosion

  摘要：

  公开号：

  EP0212752B1

文献信息

• [EN] HYDROXY CONTAINING FXR (NR1H4) MODULATING COMPOUNDS<br/>[FR] COMPOSÉS MODULATEURS DE FXR (NR1H4) CONTENANT DES GROUHYDROXY
  申请人：GILEAD SCIENCES INC

  公开号：WO2016096115A1

  公开（公告）日：2016-06-23

  The present invention relates to compounds (1) which bind to the NR1 H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds (1) for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

  本发明涉及结合NR1 H4受体（FXR）并作为FXR激动剂的化合物（1）。本发明还涉及利用这些化合物（1）制备药物以治疗疾病和/或病况，通过这些化合物结合所述核受体，并涉及这些化合物的合成过程。
• [EN] FUNGICIDAL COMPOSITION CONTAINING ACID AMIDE DERIVATIVE<br/>[FR] COMPOSITION FONGICIDE CONTENANT UN DÉRIVÉ D'AMIDE D'ACIDE
  申请人：ISHIHARA SANGYO KAISHA

  公开号：WO2006016708A1

  公开（公告）日：2006-02-16

  Conventional many fungicidal compositions have had practical problems such that either a preventive effect or a curing effect is inadequate, the residual effect tends to be inadequate, or the controlling effect against plant diseases tends to be inadequate depending upon the application site, and a fungicidal composition to overcome such problems has been desired. The present invention provides a fungicidal composition containing an acid amide derivative of the formula (I) or a salt thereof, as an active ingredient: wherein A is phenyl which may be substituted, benzyl which may be substituted, naphthyl which may be substituted, heterocyclic ring which may be substituted, fused heterocyclic ring which may be substituted, or the like; B is heterocyclic ring which may be substituted, fused heterocyclic ring which may be substituted, or naphthyl which may be substituted; each of R1 and R2 which are independent of each other, is alkyl, or the like; R3 is hydrogen, or the like; each of W1 and W2 which are independent of each other, is oxygen or sulfur.

  传统的许多杀真菌组合物存在实际问题，例如预防效果或治疗效果不足，残留效果往往不足，或者根据应用场所，控制植物病害的效果往往不足，因此需要一种能够克服这些问题的杀真菌组合物。本发明提供了一种含有式(I)的酸酰胺衍生物或其盐的杀真菌组合物作为活性成分：其中A是苯基，可能被取代，苄基，可能被取代，萘基，可能被取代，杂环环，可能被取代，融合的杂环环，可能被取代，或类似物；B是可能被取代的杂环环，融合的可能被取代的杂环环，或可能被取代的萘基；R1和R2各自独立的，是烷基，或类似物；R3是氢，或类似物；W1和W2各自独立的，是氧或硫。
• Fungicidal Composition Containing Acid Amide Derivative
  申请人：Nakamura Yuji

  公开号：US20080318779A1

  公开（公告）日：2008-12-25

  Conventional many fungicidal compositions have had practical problems such that either a preventive effect or a curing effect is inadequate, the residual effect tends to be inadequate, or the controlling effect against plant diseases tends to be inadequate depending upon the application site, and a fungicidal composition to overcome such problems has been desired. The present invention provides a fungicidal composition containing an acid amide derivative of the formula (I) or a salt thereof, as an active ingredient: wherein A is phenyl which may be substituted, benzyl which may be substituted, naphthyl which may be substituted, heterocyclic ring which may be substituted, fused heterocyclic ring which may be substituted, or the like; B is heterocyclic ring which may be substituted, fused heterocyclic ring which may be substituted, or naphthyl which may be substituted; each of R 1 and R 2 which are independent of each other, is alkyl, or the like; R 3 is hydrogen, or the like; each of W 1 and W 2 which are independent of each other, is oxygen or sulfur.

  传统的许多杀菌组合物存在实际问题，例如预防效果或治疗效果不足，残留效果倾向于不足，或者根据应用场所，对植物疾病的控制效果倾向于不足，因此需要一种克服这些问题的杀菌组合物。本发明提供了一种含有式(I)的酸酰胺衍生物或其盐作为活性成分的杀菌组合物：其中，A是苯基，可以是取代的苯基，苄基，可以是取代的苄基，萘基，可以是取代的萘基，杂环环，可以是取代的杂环环，融合的杂环环，可以是取代的融合的杂环环或类似物；B是杂环环，可以是取代的融合的杂环环或取代的萘基；R1和R2各自独立地是烷基或类似物；R3是氢或类似物；W1和W2各自独立地是氧或硫。
• FUNGICIDAL COMPOSITION CONTAINING ACID AMIDE DERIVATIVE
  申请人：Nakamura Yuji

  公开号：US20100261675A1

  公开（公告）日：2010-10-14

  Conventional many fungicidal compositions have had practical problems such that either a preventive effect or a curing effect is inadequate, the residual effect tends to be inadequate, or the controlling effect against plant diseases tends to be inadequate depending upon the application site, and a fungicidal composition to overcome such problems has been desired. The present invention provides a fungicidal composition containing an acid amide derivative of the formula (I) or a salt thereof, as an active ingredient: wherein A is phenyl which may be substituted, benzyl which may be substituted, naphthyl which may be substituted, heterocyclic ring which may be substituted, fused heterocyclic ring which may be substituted, or the like; B is heterocyclic ring which may be substituted, fused heterocyclic ring which may be substituted, or naphthyl which may be substituted; each of R 1 and R 2 which are independent of each other, is alkyl, or the like; R 3 is hydrogen, or the like; each of W 1 and W 2 which are independent of each other, is oxygen or sulfur.

  传统的多种杀菌剂组合存在实际问题，例如预防效果或治疗效果不足，残留效果往往不足，或者根据应用场所，对植物疾病的控制效果往往不足，因此需要一种能够克服这些问题的杀菌剂组合。本发明提供了一种杀菌剂组合，其包含式（I）的酸酰胺衍生物或其盐作为活性成分：其中A是苯基，可以是取代的苯基，苄基，可以是取代的苄基，萘基，可以是取代的萘基，杂环环，可以是取代的杂环环，融合的杂环环，可以是取代的融合的杂环环等；B是杂环环，可以是取代的融合的杂环环或萘基，可以是取代的萘基；R1和R2各自独立地是烷基或类似物；R3是氢或类似物；W1和W2各自独立地是氧或硫。
• HYDROXY CONTAINING FXR (NR1H4) MODULATING COMPOUNDS
  申请人：Gilead Sciences, Inc.

  公开号：US20160176861A1

  公开（公告）日：2016-06-23

  The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

  本发明涉及与NR1H4受体（FXR）结合并作为FXR激动剂的化合物。本发明进一步涉及利用这些化合物制备药物，通过这些化合物与该核受体结合治疗疾病和/或病况，以及制备这些化合物的合成过程。