2-((4-diethylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol | 1430822-93-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-((4-diethylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol
• 英文别名: 2-[4-(diethylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl]phenol
• CAS: 1430822-93-7
• 化学式: C₂₁H₂₁N₃O₂
• 分子量: 347.417
• InChiKey: BPBBBLKYCKXLGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  58.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-cyano-2-iminocoumarin 、 水杨醛 、 二乙胺 在 水 作用下， 反应 9.0h， 以83%的产率得到2-((4-diethylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol
  参考文献：
  名称：

  Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives

  摘要：

  A library of some new fluorescent chromenopyrimidine derivatives has been synthesized by new approaches. Water-promoted and one-pot reaction can produce new dialkylylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl) phenols. These compounds can also be produced using domino reaction. Two parallel methods are compared. Novel N-alkyl-N-phenyl-5H-chromeno [2,3-d] -pyrimidin-4-amines and 4-alkoxy-5H-chromeno[2, 3-d]pyrimidines are synthesized by Lewis-acid catalyzed reactions. The fluorescence emission intensity of the four compounds from each of libraries after excitation in 290 nm is measured. Compound 2-(4,5-bis(N-methyl-N-phenylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol was isolated as a byproduct. The details of an interesting exchangeable intramolecular H-bonding of two of the new compounds are reported by X-ray analysis data.

  DOI：

  10.1021/co300141j

文献信息

• Synthesis, Characterization, and Heterogeneous Catalytic Activity of Sulfamic Acid Functionalized Magnetic IRMOF‐3
  作者：Mohammad Mahdi Mostafavi、Farnaz Movahedi

  DOI：10.1002/ejic.201801054

  日期：2019.2.14

  In this work, post‐synthesis modification of Fe3O4/IRMOF‐3 nanocomposite with chlorosulfonic acid groups afforded sulfamic acid‐functionalized magnetic metal‐organic frameworks (Fe3O4/IRMOF‐3/SO3H). Functionalization was followed through FT‐IR, XRD, TGA, BET, FESEM/EDS and elemental analysis. The catalytic efficiency of the as‐prepared nanocomposite was evaluated through one‐pot pseudo four‐component

  在这项工作中，用氯磺酸基团对Fe 3 O 4 / IRMOF-3纳米复合材料进行合成后修饰提供了氨基磺酸官能化的磁性金属有机骨架（Fe 3 O 4 / IRMOF-3 / SO 3H）。通过FT-IR，XRD，TGA，BET，FESEM / EDS和元素分析进行​​功能化。在温和条件下，通过仲胺，丙二腈和水杨醛在EtOH中的一锅假四组分反应，评估了制备的纳米复合材料的催化效率。功能化IRMOF-3的磁化趋势使得可以在使用外部磁场的情况下从反应混合物中轻松倾析，随后催化剂至少可重复使用五次，而不会显着降低催化效率。
• Manganese(III) Salen Complex Immobilized on Fe₃O₄Magnetic Nanoparticles: The Efficient, Green and Reusable Nanocatalyst
  作者：Seyed Mohsen Sadeghzadeh、Faeze Daneshfar、Maryam Malekzadeh

  DOI：10.1002/cjoc.201400007

  日期：2014.4

  A new Fe3O4 magnetic nanoparticles supported manganese salen complex was successfully prepared by attaching manganese acetates to a novel N,N′‐bis(salicylidine)ethylenediamine ligand functionalized Fe3O4. The as‐prepared catalyst was characterized by TGA, XRD, FTIR, VSM, and TEM. It was found to be an efficient catalyst for the synthesis of benzopyranopyrimidines in aqueous medium. High catalytic activity

  通过将乙酸锰与新型N，N'-双（水杨基吡啶）乙二胺配体官能化的Fe 3 O 4相连，成功制备了新型的由Fe 3 O 4磁性纳米颗粒负载的锰salen络合物。所制备的催化剂通过TGA，XRD，FTIR，VSM和TEM表征。发现它是在水性介质中合成苯并吡喃并嘧啶的有效催化剂。该催化系统的其他环保特性是，高催化活性和易于使用外部磁体从反应混合物中回收的特性，以及多次重复使用而不会造成性能显着损失的特性。