N,N-bis[1,3-di-(tert-butyloxycarbonylethoxy)-isopropyl]-1',2'-diaminoethane | 287188-20-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-bis[1,3-di-(tert-butyloxycarbonylethoxy)-isopropyl]-1',2'-diaminoethane
• 英文别名: Tert-butyl 3-[2-[2-aminoethyl-[1,3-bis[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]propan-2-yl]amino]-3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]propoxy]propanoate
• CAS: 287188-20-9
• 化学式: C₃₆H₆₈N₂O₁₂
• 分子量: 720.942
• InChiKey: NHFNBLXOQPUALL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  50
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  171
• 氢给体数：
  1
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  1,3,5-苯三甲酰氯 、 N,N-bis[1,3-di-(tert-butyloxycarbonylethoxy)-isopropyl]-1',2'-diaminoethane 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以38%的产率得到Tert-butyl 3-[2-[2-[[3,5-bis[2-[bis[1,3-bis[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]propan-2-yl]amino]ethylcarbamoyl]benzoyl]amino]ethyl-[1,3-bis[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]propan-2-yl]amino]-3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]propoxy]propanoate
  参考文献：
  名称：

  Bis(1,3-dihydroxy-isopropyl)amine (BDI) as an AB4 dendritic building block: rapid synthesis of a second generation dendrimer

  摘要：

  Bis(1,3-dihydroxy-isopropyl)amine (BDI) 1, a symmetrical AB(4) dendritic building block, is developed into two diamine linkers in which the nitrogen is more nucleophilic. The four primary alcohols in BDI undergo Michael reactions with t-butyl acrylate. Branch cells of this rare multiplicity allow the rapid construction of a second generation dendrimer 5 with 48 protected peripheral primary alcohol groups. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00487-1
• 作为产物：
  描述：

  2,2′-iminobis-1,3-propanediol 在 钯 sodium hydroxide 、 sodium azide 、 氢气 、 四丁基硫酸氢铵 作用下， 以 乙酸乙酯 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 N,N-bis[1,3-di-(tert-butyloxycarbonylethoxy)-isopropyl]-1',2'-diaminoethane
  参考文献：
  名称：

  Bis(1,3-dihydroxy-isopropyl)amine (BDI) as an AB4 dendritic building block: rapid synthesis of a second generation dendrimer

  摘要：

  Bis(1,3-dihydroxy-isopropyl)amine (BDI) 1, a symmetrical AB(4) dendritic building block, is developed into two diamine linkers in which the nitrogen is more nucleophilic. The four primary alcohols in BDI undergo Michael reactions with t-butyl acrylate. Branch cells of this rare multiplicity allow the rapid construction of a second generation dendrimer 5 with 48 protected peripheral primary alcohol groups. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00487-1

文献信息

• Bis(1,3-dihydroxy-prop-2-yl) amine and derivatives thereof in the manufacture of polymers
  申请人：Fleet George W. J.

  公开号：US06916948B2

  公开（公告）日：2005-07-12

  Derivatives of bis-(1,3-dihydroxy-prop-2-yl)amine are disclosed, together with the use of such derivatives and of bis(1,3-dihydroxy-prop-2-yl)amine itself in the preparation of polymers, in particular dendrimers. Some of the derivatives may be useful as non-ionic surfactants.

  双-(1,3-二羟基丙-2-基)胺的衍生物被披露，以及在聚合物制备中使用这些衍生物和双(1,3-二羟基丙-2-基)胺本身，特别是在树枝状聚合物的制备中。其中一些衍生物可能用作非离子表面活性剂。
• Bis(1,3-dihydroxy-isopropyl)amine (BDI) as an AB4 dendritic building block: rapid synthesis of a second generation dendrimer
  作者：David A Scott、Thomas M Krülle、Malcolm Finn、George W.J Fleet

  DOI：10.1016/s0040-4039(00)00487-1

  日期：2000.5

  Bis(1,3-dihydroxy-isopropyl)amine (BDI) 1, a symmetrical AB(4) dendritic building block, is developed into two diamine linkers in which the nitrogen is more nucleophilic. The four primary alcohols in BDI undergo Michael reactions with t-butyl acrylate. Branch cells of this rare multiplicity allow the rapid construction of a second generation dendrimer 5 with 48 protected peripheral primary alcohol groups. (C) 2000 Elsevier Science Ltd. All rights reserved.