5-ethyl-3-hydroxy-dihydro-furan-2-one | 81644-93-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 5-ethyl-3-hydroxy-dihydro-furan-2-one
• 英文别名: 5-Aethyl-3-hydroxy-dihydro-furan-2-on；4-Ethyl-2-hydroxy-gamma-butyrolactone；5-ethyl-3-hydroxyoxolan-2-one
• CAS: 81644-93-1
• 化学式: C₆H₁₀O₃
• 分子量: 130.144
• InChiKey: NFHHVCIAYGZHKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  丙烯酸乙酯 、 Ethyl 2,4-dihydroxyhexanoate 、 、 5-ethyl-3-hydroxy-dihydro-furan-2-one 、 以 丙醇 为溶剂， 生成 山梨酸乙酯
  参考文献：
  名称：

  Catalyst comprised of n-substituted cyclic imides and processes for preparing organic compounds with the catalyst

  摘要：

  该发明的催化剂包括具有以下式子(I)所表示的N-取代环状酰亚胺骨架的酰亚胺化合物：其中R是羟基保护基。首选的R是可水解的保护基。R可以是通过从酸中消除OH基团获得的基团。这些酸包括例如羧酸、磺酸、碳酸、氨基甲酸、硫酸、硝酸、磷酸和硼酸。催化剂可以包括酰亚胺化合物和金属化合物的组合。在催化剂的存在下，使能够形成自由基的化合物(A)与自由基清除化合物(B)反应，从而生成化合物(A)和化合物(B)或其衍生物的加成或取代反应产物。该催化剂可以在温和条件下产生高选择性和高收率的有机化合物，例如加成或取代反应的产物。

  公开号：

  US20040053778A1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 5-ethyl-3-hydroxy-dihydro-furan-2-one
  参考文献：
  名称：

  Helferich; Speidel, Chemische Berichte, 1921, vol. 54, p. 2637

  摘要：

  DOI：

文献信息

• Catalyst comprising n-substituted cylic imides and processes for preparing organic compounds with the catalyst
  申请人：——

  公开号：US20030013603A1

  公开（公告）日：2003-01-16

  A catalyst of the invention includes an imide compound having a N-substituted cyclic imide skeleton represented by following Formula (I): 1 wherein R is a hydroxyl-protecting group. Preferred R is a hydrolyzable protecting group. R may be a group obtained from an acid by eliminating an OH group therefrom. Such acids include, for example, carboxylic acids, sulfonic acids, carbonic acid, carbamic acid, sulfuric acid, nitric acid, phosphoric acids and boric acids. The catalyst may include the imide compound and a metallic compound in combination. In the presence of the catalyst, (A) a compound capable of forming a radical is allowed to react with (B) a radical scavenging compound and thereby yields an addition or substitution reaction product of the compound (A) and the compound (B) or a derivative thereof. This catalyst can produce an organic compound with a high selectivity in a high yield as a result of, for example, an addition or substitution reaction under mild conditions.

  该发明的催化剂包括具有以下式（I）所表示的N-取代环状亚酰胺骨架的亚酰胺化合物：其中R是羟基保护基。首选R是可水解的保护基。R可以是从酸中消除OH基团得到的基团。这些酸包括例如羧酸，磺酸，碳酸，氨基甲酸，硫酸，硝酸，磷酸和硼酸。催化剂可以包括亚酰胺化合物和金属化合物的组合。在催化剂的存在下，将能够形成自由基的化合物（A）与自由基清除化合物（B）反应，从而生成化合物（A）和化合物（B）或其衍生物的加成或取代反应产物。该催化剂可以在温和条件下通过加成或取代反应以高选择性高产率地产生有机化合物。
• Catalyst comprising cyclic acylurea compounds and processes for production organic compounds with the same
  申请人：Ishii Yasutaka

  公开号：US20050020439A1

  公开（公告）日：2005-01-27

  A catalyst of the invention includes a cyclic acylurea compound having a cyclic acylurea skeleton represented by following Formula (I): wherein R is a hydrogen atom or a hydroxyl-protecting group; n is 1 or 2; G is a carbon atom or a nitrogen atom, where two Gs are the same or different when n is 2. The catalyst may include the cyclic acylurea compound and a metallic compound in combination. In the presence of the catalyst, (A) a compound capable of forming a radical is allowed to react with (B) a radical scavenging compound and thereby yields an addition or substitution reaction product of the compound (A) and the compound (B) or a derivative thereof. This catalyst can produce an organic compound with a high selectivity in a high yield as a result of, for example, an addition or substitution reaction under mild conditions.

  该发明的催化剂包括具有下式表示的环状酰脲骨架的环状酰脲化合物（I）：其中R是氢原子或羟基保护基；n为1或2；G是碳原子或氮原子，当n为2时，两个G可以相同或不同。该催化剂可以包括环状酰脲化合物和金属化合物的组合物。在催化剂的存在下，（A）能够形成自由基的化合物与（B）自由基清除化合物反应，从而产生化合物（A）和化合物（B）或其衍生物的加成或取代反应产物。该催化剂可以在温和条件下通过加成或取代反应产生高选择性和高产率的有机化合物。
• Catalyst comprising cyclic acylurea compound and process for producing organic compounds using the catalyst
  申请人：Ishii Yasutaka

  公开号：US20060030716A1

  公开（公告）日：2006-02-09

  A catalyst of the invention includes a cyclic acylurea compound having a cyclic acylurea skeleton represented by following Formula (I): wherein R is a hydrogen atom or a hydroxyl-protecting group; n is 1 or 2; G is a carbon atom or a nitrogen atom, where two Gs are the same or different when n is 2. The catalyst may include the cyclic acylurea compound and a metallic compound in combination. In the presence of the catalyst, (A) a compound capable of forming a radical is allowed to react with (B) a radical scavenging compound and thereby yields an addition or substitution reaction product of the compound (A) and the compound (B) or a derivative thereof. This catalyst can produce an organic compound with a high selectivity in a high yield as a result of, for example, an addition or substitution reaction under mild conditions.

  本发明的催化剂包括具有以下式（I）所表示的环状酰基脲骨架的环状酰基脲化合物，其中R是氢原子或羟基保护基；n为1或2；G为碳原子或氮原子，当n为2时，两个G可以相同或不同。该催化剂可以包括环状酰基脲化合物和金属化合物的组合。在催化剂的存在下，将（A）能够形成自由基的化合物与（B）自由基清除化合物反应，从而产生化合物（A）和化合物（B）或其衍生物的加成或取代反应产物。该催化剂可以在温和的条件下通过加成或取代反应产生高选择性的有机化合物，从而获得高收率。
• Catalyst comprising a cyclic imide compound and process for producing organic compounds using the catalyst
  申请人：Ishii Yasutaka

  公开号：US20060036100A1

  公开（公告）日：2006-02-16

  A catalyst includes a cyclic imide compound having an N-substituted cyclic imide skeleton represented by following Formula (I): wherein X is an oxygen atom or a hydroxyl group, and having a solubility parameter of less than or equal to 26 [(MPa) 1/2 ] as determined by Fedors method. The catalyst may further comprise a metallic compound. By allowing (A) a compound capable of forming a radical to react with (B) a radical scavenging compound in the presence of the catalyst, an addition or substitution reaction product between the compound (A) and the compound (B) or a derivative thereof can be obtained.

  催化剂包括一个具有N-取代的环状酰亚胺骨架的环状酰亚胺化合物，其表示如下式(I)：其中X是氧原子或羟基，并且具有由Fedors方法确定的溶解度参数小于或等于26[(MPa)1/2]。催化剂还可以包括一种金属化合物。通过在催化剂存在下使(A)能够形成自由基的化合物与(B)自由基清除化合物反应，可以获得化合物(A)和化合物(B)或其衍生物之间的加成或取代反应产物。
• Catalyst comprised of n-substituted cyclic imides and processes for preparing organic compounds with the catalyst
  申请人：——

  公开号：US20040053778A1

  公开（公告）日：2004-03-18

  A catalyst of the invention includes an imide compound having a N-substituted cyclic imide skeleton represented by following Formula (I): 1 wherein R is a hydroxyl-protecting group. Preferred R is a hydrolyzable protecting group. R may be a group obtained from an acid by eliminating an OH group therefrom. Such acids include, for example, carboxylic acids, sulfonic acids, carbonic acid, carbamic acid, sulfuric acid, nitric acid, phosphoric acids and boric acids. The catalyst may include the imide compound and a metallic compound in combination. In the presence of the catalyst, (A) a compound capable of forming a radical is allowed to react with (B) a radical scavenging compound and thereby yields an addition or substitution reaction product of the compound (A) and the compound (B) or a derivative thereof. This catalyst can produce an organic compound with a high selectivity in a high yield as a result of, for example, an addition or substitution reaction under mild conditions.

  该发明的催化剂包括具有以下式子(I)所表示的N-取代环状酰亚胺骨架的酰亚胺化合物：其中R是羟基保护基。首选的R是可水解的保护基。R可以是通过从酸中消除OH基团获得的基团。这些酸包括例如羧酸、磺酸、碳酸、氨基甲酸、硫酸、硝酸、磷酸和硼酸。催化剂可以包括酰亚胺化合物和金属化合物的组合。在催化剂的存在下，使能够形成自由基的化合物(A)与自由基清除化合物(B)反应，从而生成化合物(A)和化合物(B)或其衍生物的加成或取代反应产物。该催化剂可以在温和条件下产生高选择性和高收率的有机化合物，例如加成或取代反应的产物。