N'-(2-aminoethyl)-N'-[2-(1,4-dioxaspiro[4.5]decan-8-ylamino)ethyl]ethane-1,2-diamine | 129323-75-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N'-(2-aminoethyl)-N'-[2-(1,4-dioxaspiro[4.5]decan-8-ylamino)ethyl]ethane-1,2-diamine
• CAS: 129323-75-7
• 化学式: C₁₄H₃₀N₄O₂
• 分子量: 286.418
• InChiKey: OTRMQUHKCYXQBZ-UHFFFAOYSA-N

物化性质

• 沸点：
  421.1±45.0 °C(Predicted)
• 密度：
  1.11±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  85.8
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 N'-(2-aminoethyl)-N'-[2-(1,4-dioxaspiro[4.5]decan-8-ylamino)ethyl]ethane-1,2-diamine 在 甲酸 作用下， 以 水 为溶剂， 以60%的产率得到N'-[2-(dimethylamino)ethyl]-N'-[2-[1,4-dioxaspiro[4.5]decan-8-yl(methyl)amino]ethyl]-N,N-dimethylethane-1,2-diamine
  参考文献：
  名称：

  Cholesterol-lowering bile acid-binding agents: novel lipophilic polyamines

  摘要：

  A series of novel lipophilic polyamines was synthesized by the sodium cyanoborohydride-mediated reductive amination of various ketones and aldehydes with the polyamine tris(2-aminoethyl)amine. Two of these compounds, N,N-bis[2-(cyclododecylamino)ethyl]-N'-benzyl-1,2-ethanediamine trihydrochloride (36.3HCl) and N,N-bis[2-(cyclododecylmethylamino)ethyl]-N',N'-dimethyl-1,2-ethaediamine (23), are 29 and 24 times more potent than colestipol hydrochloride, respectively, for lowering animal serum cholesterol levels.

  DOI：

  10.1021/jm00085a011
• 作为产物：
  描述：

  1,4-环己二酮单乙二醇缩酮 、 三(2-氨基乙基)胺 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 生成 N'-(2-aminoethyl)-N'-[2-(1,4-dioxaspiro[4.5]decan-8-ylamino)ethyl]ethane-1,2-diamine
  参考文献：
  名称：

  Cholesterol-lowering bile acid-binding agents: novel lipophilic polyamines

  摘要：

  A series of novel lipophilic polyamines was synthesized by the sodium cyanoborohydride-mediated reductive amination of various ketones and aldehydes with the polyamine tris(2-aminoethyl)amine. Two of these compounds, N,N-bis[2-(cyclododecylamino)ethyl]-N'-benzyl-1,2-ethanediamine trihydrochloride (36.3HCl) and N,N-bis[2-(cyclododecylmethylamino)ethyl]-N',N'-dimethyl-1,2-ethaediamine (23), are 29 and 24 times more potent than colestipol hydrochloride, respectively, for lowering animal serum cholesterol levels.

  DOI：

  10.1021/jm00085a011

文献信息

• LIPOPHILIC POLYAMINES USEFUL FOR TREATING HYPERCHOLESTEROLEMIA
  申请人：THE UPJOHN COMPANY

  公开号：EP0424385A1

  公开（公告）日：1991-05-02
• US5192798A
  申请人：——

  公开号：US5192798A

  公开（公告）日：1993-03-09
• [EN] LIPOPHILIC POLYAMINES USEFUL FOR TREATING HYPERCHOLESTEROLEMIA
  申请人：THE UPJOHN COMPANY

  公开号：WO1989008098A2

  公开（公告）日：1989-09-08

  (EN) This invention relates to novel lipophilic polyamides of the formula Z1-(CH2)n-Y1-X1-R1, the method of using these compounds to treat hypercholesterolemia, and intermediates thereto.(FR) Cette invention concerne de nouvelles polyamines lipophiles de la formule Z1-(CH2)n-Y1-X1-R1, le procédé d'utilisation de ces composés afin de traiter l'hypercholestérolémie, ainsi que des intermédiaires de ceux-ci.
• Cholesterol-lowering bile acid-binding agents: novel lipophilic polyamines
  作者：Edward W. Thomas、Michele M. Cudahy、Charles H. Spilman、Dac M. Dinh、Tommie L. Watkins、Thomas J. Vidmar

  DOI：10.1021/jm00085a011

  日期：1992.4

  A series of novel lipophilic polyamines was synthesized by the sodium cyanoborohydride-mediated reductive amination of various ketones and aldehydes with the polyamine tris(2-aminoethyl)amine. Two of these compounds, N,N-bis[2-(cyclododecylamino)ethyl]-N'-benzyl-1,2-ethanediamine trihydrochloride (36.3HCl) and N,N-bis[2-(cyclododecylmethylamino)ethyl]-N',N'-dimethyl-1,2-ethaediamine (23), are 29 and 24 times more potent than colestipol hydrochloride, respectively, for lowering animal serum cholesterol levels.