2-[4-(N,N-Dimethylaminomethyl)phenyl]-4-(4-fluorophenyl)-5-(2-phenoxy-4-pyrimidinyl)imidazole | 217661-96-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[4-(N,N-Dimethylaminomethyl)phenyl]-4-(4-fluorophenyl)-5-(2-phenoxy-4-pyrimidinyl)imidazole
• 英文别名: 1-[4-[4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl)-1H-imidazol-2-yl]phenyl]-N,N-dimethylmethanamine
• CAS: 217661-96-6
• 化学式: C₂₈H₂₄FN₅O
• 分子量: 465.53
• InChiKey: HSSDJLDUDQKZSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  、 亚磷酸三乙酯 在 水 、 magnesium sulfate 、 silica gel 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 16.0h， 以to give the title compound as a yellow foam (0.094 g, 30%)的产率得到2-[4-(N,N-Dimethylaminomethyl)phenyl]-4-(4-fluorophenyl)-5-(2-phenoxy-4-pyrimidinyl)imidazole
  参考文献：
  名称：

  Aryloxy substituted pyrimidine imidazole compounds

  摘要：

  小说2,4,5-三芳基取代咪唑类化合物和用于治疗CSBP/RK/p38介导疾病的组合物。

  公开号：

  US06610695B1

文献信息

• Methods for promoting survival of transplanted tissues and cells
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：EP1676574A2

  公开（公告）日：2006-07-05

  Methods for enhancing the survival of a cell, tissue, or organ transplanted into a recipient comprising contacting the cell, tissue, or organ graft with an agent that decreases the rate of coagulation on the transplanted cell, tissue or organ are disclosed. The agent is one that acts by reducing the amount or activity of tissue factor (TF) on the donor tissue, such as a p38 MAPK inhibitor, a JNK inhibitor, a p38 MAPK/JNK dual inhibitor and a TF antagonist. Cells, tissues and organs treated with those agents are also disclosed.

  本发明公开了提高移植到受者体内的细胞、组织或器官存活率的方法，该方法包括使细胞、组织或器官移植体与一种能降低移植细胞、组织或器官凝血率的药剂接触。这种药剂通过减少供体组织上组织因子（TF）的数量或活性发挥作用，如 p38 MAPK 抑制剂、JNK 抑制剂、p38 MAPK/JNK 双抑制剂和 TF 拮抗剂。还公开了用这些制剂处理的细胞、组织和器官。
• Methods of promoting osteogenesis
  申请人：——

  公开号：US20040162289A1

  公开（公告）日：2004-08-19

  The invention is directed to methods of bone healing by administering a p38 MAP kinase inhibitor. The invention is directed to methods of treating bone fractures, bone diseases, bone grafting, especially enhancing bone healing following facial reconstruction, maxillary reconstruction, mandibular reconstruction or tooth extraction, enhancing long bone extension, enhancing prosthetic ingrowth, and increasing bone synostosis by administering a p38 MAP kinase inhibitor.

  本发明涉及通过施用 p38 MAP 激酶抑制剂促进骨愈合的方法。本发明涉及通过施用 p38 MAP 激酶抑制剂来治疗骨折、骨病、骨移植，特别是在面部重建、上颌骨重建、下颌骨重建或拔牙后增强骨愈合、增强长骨延伸、增强假体植入和增加骨合的方法。
• Methods for treating diabetes
  申请人：——

  公开号：US20040171659A1

  公开（公告）日：2004-09-02

  The invention is directed to methods of treating diabetes by administering p38 mitogen activated protein kinase inhibitors. The invention is also directed to methods of decreasing blood glucose level in diabetes patients by administering p38 mitogen activated protein kinase inhibitors.

  本发明涉及通过施用 p38 丝裂原活化蛋白激酶抑制剂治疗糖尿病的方法。本发明还涉及通过施用 p38 丝裂原活化蛋白激酶抑制剂降低糖尿病患者血糖水平的方法。
• Stents and intra-luminal prostheses containing map kinase inhibitors
  申请人：Schreiner F. George

  公开号：US20050129729A1

  公开（公告）日：2005-06-16

  A coated stent or intra-luminal prosthesis containing a MAP kinase inhibitor controls, reduces, or prevents restenosis, inflammation, and complications associated with stent or intra-luminal prosthesis implantation and/or cardiovascular disease.

  含有 MAP 激酶抑制剂的涂层支架或腔内假体可控制、减少或预防与支架或腔内假体植入和/或心血管疾病相关的再狭窄、炎症和并发症。
• Treatment of cardiovascular disease with inhibitors of p38 kinase
  申请人：Higgins S. Linda

  公开号：US20060019971A1

  公开（公告）日：2006-01-26

  The present invention concerns methods of treatment for acute coronary syndrome using a pharmaceutically effective amount of an inhibitor of p38 MAP kinase. More specifically, the invention concerns the treatment of cardiovascular disorders associated with atherosclerosis.

  本发明涉及使用药学有效量的 p38 MAP 激酶抑制剂治疗急性冠状动脉综合征的方法。更具体地说，本发明涉及与动脉粥样硬化相关的心血管疾病的治疗。