2-[(3'-(dimethylamino)propyl)amino]-8,9-methylenedioxybenzo[c][1,7]phenanthroline | 1228814-13-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[(3'-(dimethylamino)propyl)amino]-8,9-methylenedioxybenzo[c][1,7]phenanthroline
• 英文别名: N-([1,3]benzodioxolo[5,6-c][1,7]phenanthrolin-2-yl)-N',N'-dimethylpropane-1,3-diamine
• CAS: 1228814-13-8
• 化学式: C₂₂H₂₂N₄O₂
• 分子量: 374.442
• InChiKey: LHUKMJPFBJVDEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  59.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-chloro-8,9-methylenedioxybenzo[c][1,7]phenanthroline 、 N,N-二甲基-1,3-二氨基丙烷 以31%的产率得到2-[(3'-(dimethylamino)propyl)amino]-8,9-methylenedioxybenzo[c][1,7]phenanthroline
  参考文献：
  名称：

  Synthesis and biological evaluation of dialkylaminoalkylamino benzo[c][1,7] and [1,8]phenanthrolines as antiproliferative agents

  摘要：

  Benzo[c][1,7] and [1,8]phenanthroline substituted by dialkylaminoalkyl side chains at position C2 and C1, respectively, were synthesized and their biological activity evaluated. These compounds displayed more potent cytotoxicity toward L1210 cells than the parent unsubstituted compounds, associated with strong DNA interaction. The moderate Topol inhibitory activity induced by the novel compounds suggests that other cellular targets should be responsible for the antiproliferative activity.

  DOI：

  10.1016/j.ejmech.2010.02.043