(-)-β-methyl-α-methylene-γ-butyrolactone | 110098-10-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (-)-β-methyl-α-methylene-γ-butyrolactone
• 英文别名: 3-methylene-4(S)-methyldihydro-2-furanone；(4S)-4-methyl-3-methylideneoxolan-2-one
• CAS: 110098-10-7
• 化学式: C₆H₈O₂
• 分子量: 112.128
• InChiKey: ZFHFDZCWLKLJPP-SCSAIBSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (-)-β-methyl-α-methylene-γ-butyrolactone 、 Boc-Cys-Ala-OMe 以 乙醇 为溶剂， 反应 120.0h， 以93%的产率得到(-)-β-methyl-α-methylene-γ-butyrolactone-Cys(Boc)-Ala(OMe) adduct
  参考文献：
  名称：

  BOC-CYS-ALA-OME的合成及其对α-亚甲基-γ-丁内酯的立体选择性加成

  摘要：

  已经研究了对映体纯（如200 MHz 1 H NMR研究所示）向α-亚甲基-γ-丁内酯中立体定向加成的二肽Boc-Cys-Ala-OMe 4。添加的立体选择性与在豚鼠诱发的过敏性接触性皮炎中观察到的对映选择性平行。

  DOI：

  10.1016/s0040-4020(01)81082-6
• 作为产物：
  描述：

  在 碘甲烷 作用下， 以 甲醇 为溶剂， 反应 20.0h， 生成 (-)-β-methyl-α-methylene-γ-butyrolactone
  参考文献：
  名称：

  Stereospecificity in allergic contact dermatitis to simple substituted methylene lactones derivatives

  摘要：

  The enantiomers of beta,gamma-dimethyl- and beta-methyl-alpha-methylene-gamma-butyrolactones have been synthesized stereospecifically from glutamic acid and beta-hydroxy isobutyric acid, respectively. Guinea pigs have been sensitized (Freund complete adjuvant technique) and tested to them. Both enantiomers of beta-methyl lactone as well as (+)-beta,gamma-dimethyl lactone induced enantiospecific allergic contact dermatitis (ACD); in turn, (-)-beta,gamma-dimethyl lactone showed no specificity. An interpretation is proposed.

  DOI：

  10.1021/jm00394a003

文献信息

• POLYMER COMPOSITION, PLASTIC OPTICAL FIBER, PLASTIC OPTICAL FIBER CABLE AND METHOD FOR PRODUCING PLASTIC OPTICAL FIBER
  申请人：MITSUBISHI RAYON CO., LTD.

  公开号：EP1834968A1

  公开（公告）日：2007-09-19

  There is provided a polymer composition comprising 5 to 100% by mass of a unit (A) of a lactone compound represented by a general formula (1) and 0 to-95% by mass of a unit (B) of (meth)acrylate as constitutional units, wherein the unit (A) of a lactone compound comprises a unit of an (S) isomer represented by a general formula (2) and a unit of an (R) isomer represented by a general formula (3) at a mass ratio of from 70/30 to 30/70; and wherein the polymer composition has a total light scattering loss of not more than 100 dB/km. The polymer composition is excellent in heat resistance and transparency.

  本发明提供了一种聚合物组合物，该聚合物组合物包含 5%至 100%（以质量计）的通式（1）所代表的内酯化合物单元（A）和 0%至 95%（以质量计）的（甲基）丙烯酸酯单元（B）作为组成单元，其中内酯化合物单元（A）包含通式（2）所代表的（S）异构体单元和通式（3）所代表的（R）异构体单元，两者的质量比为 70/30 至 30/70；其中聚合物组合物的总光散射损耗不超过 100 dB/km。该聚合物组合物具有优异的耐热性和透明度。
• TALAGA, PATRICE;SHAEFFER, MARCEL;MATTES, HENRI;BENEZRA, CLAUDE;STAMPF, JE+, TETRAHEDRON, 45,(1989) N6, C. 5029-5038
  作者：TALAGA, PATRICE、SHAEFFER, MARCEL、MATTES, HENRI、BENEZRA, CLAUDE、STAMPF, JE+

  DOI：——

  日期：——
• MATTES, HENRI;HAMADA, KAORU;BENEZRA, CLAUDE, J. MED. CHEM., 30,(1987) N 11, 1948-1951
  作者：MATTES, HENRI、HAMADA, KAORU、BENEZRA, CLAUDE

  DOI：——

  日期：——
• Polymer Composition, Plastic Optical Fiber, Plastic Optical Fiber Cable, and Method for Manufacturing Plastic Optical Fiber
  申请人：Aoyagi Amane

  公开号：US20080166091A1

  公开（公告）日：2008-07-10

  There is provided a polymer composition comprising 5 to 100% by mass of a unit (A) of a lactone compound represented by a general formula (1) and 0 to 95% by mass of a unit (B) of (meth)acrylate as constitutional units, wherein the unit (A) of a lactone compound comprises a unit of an (S) isomer represented by a general formula (2) and a unit of an (R) isomer represented by a general formula (3) at a mass ratio of from 70/30 to 30/70; and wherein the polymer composition has a total light scattering loss of not more than 100 dB/km. The polymer composition is excellent in heat resistance and transparency.
• US7512309B2
  申请人：——

  公开号：US7512309B2

  公开（公告）日：2009-03-31