7,7-ethylenedioxybiclo[3.3.1]nonan-exo-3-ol | 207791-19-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7,7-ethylenedioxybiclo[3.3.1]nonan-exo-3-ol
• CAS: 207791-19-3
• 化学式: C₁₁H₁₈O₃
• 分子量: 198.262
• InChiKey: SKTTUNNKILBHML-MYJAWHEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.69
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  7,7-ethylenedioxybiclo[3.3.1]nonan-exo-3-ol 在 溶剂黄146 作用下， 以 水 为溶剂， 反应 2.0h， 以86%的产率得到(1S,5R,7R)-7-Hydroxy-bicyclo[3.3.1]nonan-3-one
  参考文献：
  名称：

  Synthesis and evaluation of tacrine–Huperzine a hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of alzheimer’s disease

  摘要：

  Seventeen polycyclic compounds related to tacrine and huperzine A have been prepared as racemic mixtures and tested as acetylcholinesterase (AChE) inhibitors. The conjunctive pharmacomodulation of huperzine A (carbobicyclic substructure) and tacrine (4-aminoquinoline substructure) led to compound 7jy, 2.5 times less active than tacrine as AChE inhibitor, but much more active than its (Z)-stereoisomer (7iy). Derivatives 7dy and 7ey, lacking the ethylidene substituent, showed to be more active than tacrine. Many other structural modifications of 7jy led to less active compounds. Compounds 7dy and 7ey also showed to be much more active than tacrine in reversing the partial neuromuscular blockade induced by d-tubocurarine. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00015-7
• 作为产物：
  描述：

  spiro[bicyclo[3.3.1]nonane-3,2'-[1,3]dioxolan]-7-one 在 sodium 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以80%的产率得到7,7-ethylenedioxybiclo[3.3.1]nonan-exo-3-ol
  参考文献：
  名称：

  Synthesis and evaluation of tacrine–Huperzine a hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of alzheimer’s disease

  摘要：

  Seventeen polycyclic compounds related to tacrine and huperzine A have been prepared as racemic mixtures and tested as acetylcholinesterase (AChE) inhibitors. The conjunctive pharmacomodulation of huperzine A (carbobicyclic substructure) and tacrine (4-aminoquinoline substructure) led to compound 7jy, 2.5 times less active than tacrine as AChE inhibitor, but much more active than its (Z)-stereoisomer (7iy). Derivatives 7dy and 7ey, lacking the ethylidene substituent, showed to be more active than tacrine. Many other structural modifications of 7jy led to less active compounds. Compounds 7dy and 7ey also showed to be much more active than tacrine in reversing the partial neuromuscular blockade induced by d-tubocurarine. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00015-7