| 1446422-71-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• CAS: 1446422-71-4
• 化学式: C₁₅H₃₂NO₉PS
• 分子量: 433.46
• InChiKey: XZHICELFUJMUGF-ISZNTPMXSA-N

反应信息

• 作为反应物：
  描述：

  在 双氧水 、 sodium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 50.0h， 生成 tert-butyl N-[(1R)-3-amino-1-[diethoxymethyl(ethoxy)phosphoryl]-3-oxopropyl]carbamate
  参考文献：
  名称：

  Enantioselective Synthesis of H-Phosphinic Acids Bearing Natural Amino Acid Residues

  摘要：

  The first systematic study on the asymmetric synthesis of H-phosphinic acids bearing natural protein amino acid residues was reported on the basis of the asymmetric addition of ethyl diethoxymethylphosphinate to N-tert-butane-sulfinyl imines. Good yields and moderate to high enantiose-lectivities were obtained. Reliable methods were developed for the elucidation of the stereochemistry of these phosphinic acids and derivatives thereof. The transformation of the side chains of these analogues was studied. Methods for the conversion of the alpha-aminophosphinates to oligopetides were reported.

  DOI：

  10.1021/jo400798f
• 作为产物：
  描述：

  在 盐酸 、 4-二甲氨基吡啶 、 10 wt% Pd(OH)2 on carbon 、 氢气 、 三乙胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 反应 4.25h， 生成
  参考文献：
  名称：

  Enantioselective Synthesis of H-Phosphinic Acids Bearing Natural Amino Acid Residues

  摘要：

  The first systematic study on the asymmetric synthesis of H-phosphinic acids bearing natural protein amino acid residues was reported on the basis of the asymmetric addition of ethyl diethoxymethylphosphinate to N-tert-butane-sulfinyl imines. Good yields and moderate to high enantiose-lectivities were obtained. Reliable methods were developed for the elucidation of the stereochemistry of these phosphinic acids and derivatives thereof. The transformation of the side chains of these analogues was studied. Methods for the conversion of the alpha-aminophosphinates to oligopetides were reported.

  DOI：

  10.1021/jo400798f