6-nitro-1H-quinoline-2,4-dione | 863723-28-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-nitro-1H-quinoline-2,4-dione
• 英文别名: 2-hydroxy-6-nitrobenzopyridine-4-one；4-hydroxy-6-nitro-3H-quinolin-2-one
• CAS: 863723-28-8
• 化学式: C₉H₆N₂O₄
• 分子量: 206.158
• InChiKey: YLEXWDNWEMQBHE-UHFFFAOYSA-N

物化性质

• 沸点：
  491.2±45.0 °C(Predicted)
• 密度：
  1.503±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  92
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-nitro-1H-quinoline-2,4-dione 在 三溴氧磷 作用下， 反应 3.0h， 生成 2,4-二溴-6-硝基喹啉
  参考文献：
  名称：

  Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 4: 3-Alkyl-4-halo-6-nitroquipazines

  摘要：

  On the basis of the structure activity relationship (SAR) of 4-chloro-6-nitroquipazine (K-i = 0.03 nM) and 3-fluoropropyl-6-nitroquipazine (K-i = 0.32 nM), 3-alkyl-4-halo-6-nitroquipazines were synthesized and tested for their potential abilities in vitro to displace [H-3]citalopram binding to the rat cortical membranes. Binding affinities of 3h and 4d were K-i = 2.70 +/- 0.32 and 2.23 +/- 0.46 nM. respectively. The syntheses of 3-alkyl-4-halo-6-nitroquipazine. their in vitro binding affinitics. and the SAR of C3, C4 position in 6-nitroquipazine are described. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.05.031
• 作为产物：
  描述：

  3-(4-硝基苯胺基)-3-氧代丙酸乙酯 在 PPA 作用下， 反应 2.5h， 生成 6-nitro-1H-quinoline-2,4-dione
  参考文献：
  名称：

  Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 4: 3-Alkyl-4-halo-6-nitroquipazines

  摘要：

  On the basis of the structure activity relationship (SAR) of 4-chloro-6-nitroquipazine (K-i = 0.03 nM) and 3-fluoropropyl-6-nitroquipazine (K-i = 0.32 nM), 3-alkyl-4-halo-6-nitroquipazines were synthesized and tested for their potential abilities in vitro to displace [H-3]citalopram binding to the rat cortical membranes. Binding affinities of 3h and 4d were K-i = 2.70 +/- 0.32 and 2.23 +/- 0.46 nM. respectively. The syntheses of 3-alkyl-4-halo-6-nitroquipazine. their in vitro binding affinitics. and the SAR of C3, C4 position in 6-nitroquipazine are described. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.05.031

文献信息

• 一种糖精衍生物有机颜料及制备方法
  申请人：江苏丽王科技股份有限公司

  公开号：CN113861180A

  公开（公告）日：2021-12-31

  本发明提供一种糖精衍生物有机颜料及制备方法，将糖精、苯并吡啶‑4‑酮及衍生物按摩尔比1:1投入到反应器中，选用溶剂水、甲醇、乙醇、丙醇、异丙醇、吡啶、正丁醇等作为溶剂，在64‑140℃搅拌反应3‑36小时，得到有机颜料。本发明制备的有机颜料合成过程简单，合成产物收率高，结构中有丰富的羰基，酰胺基，磺酰基，吡啶酮和苯环结构，所得到的颜料耐溶剂、耐日晒，耐温性能优异。