1,4-di(4'-methoxyphenyl)-2-fluorobenzene | 164918-12-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-di(4'-methoxyphenyl)-2-fluorobenzene
• 英文别名: 2'-fluoro-4,4''-dimethoxy-1,1':4',1''-terphenyl；2-Fluoro-1,4-bis(4-methoxyphenyl)benzene
• CAS: 164918-12-1
• 化学式: C₂₀H₁₇FO₂
• 分子量: 308.352
• InChiKey: MXXDLGGWUGXGLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,4-di(4'-methoxyphenyl)-2-fluorobenzene 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以53.6%的产率得到2-fluoro-1,4-phenylene-bis(4-hydroxybenzene)
  参考文献：
  名称：

  Polymerizable compound having conjugated bonds, liquid crystal composition and liquid crystal display device

  摘要：

  提供一种具有高聚合反应性、高转化产率和在液晶组合物中具有高溶解度的可聚合化合物，包括该化合物的可聚合组合物，由该可聚合组合物制备的液晶复合物以及含有该复合物的液晶显示装置的主题的翻译。解决该主题的方法是通过公式（1）表示的化合物、液晶组合物和液晶显示装置。在该公式中，例如，环A1、环A2和环A4为苯基或环己基；Sp1和Sp2为具有1至6个碳原子的单键或烷基；Z1和Z2为—CH═CH—或—C≡C—；a为1，b为0；P1和P2为可聚合基团。

  公开号：

  US10253259B2
• 作为产物：
  描述：

  4-甲氧基苯硼酸 、 1,4-二溴-2-氟苯 在 四(三苯基膦)钯 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 以52%的产率得到1,4-di(4'-methoxyphenyl)-2-fluorobenzene
  参考文献：
  名称：

  通过1,4-二溴-2-氟苯的位置选择性Suzuki-Miyaura反应一锅合成氟化三联苯

  摘要：

  1，4-二溴-2-氟苯与两当量的芳基硼酸的Suzuki-Miyaura反应产生了氟化的对三联苯。与1当量的芳基硼酸的反应导致联苯的位点选择性形成。1，4-二溴-2-氟苯与两种不同的芳基硼酸的一锅法反应得到含两个不同的末端芳基的氟化对-三联苯。

  DOI：

  10.1016/j.tetlet.2010.03.067

文献信息

• Synthesis of functionalized fluorinated terphenyls by site-selective Suzuki–Miyaura cross-coupling reactions of dibrominated fluorobenzenes
  作者：Muhammad Sharif、Aneela Maalik、Sebastian Reimann、Holger Feist、Jamshed Iqbal、Tamás Patonay、Alexander Villinger、Peter Langer

  DOI：10.1016/j.jfluchem.2012.12.003

  日期：2013.2

  A variety of fluorinated terphenyls were prepared by site-selective Suzuki–Miyaura cross-coupling reactions of dibrominated fluorobenzenes, such as 1,2-dibromo-3,5-difluorobenzene, 1,4-dibromo-2-fluorobenzene, 1,3-dibromo-4-fluorobenzene, and 1,2-dibromo-4-fluorobenzene.

  通过二溴氟苯的定点Suzuki-Miyaura交叉偶联反应制备了多种氟化三联苯，例如1,2-二溴-3,5-二氟苯，1,4-二溴-2-氟苯，1,3-二溴-4-氟苯，和1,2-二溴-4-氟苯。
• Synthesis of Terphenyl Derivatives by Pd-Catalyzed Suzuki-Miyaura Reaction of Dibromobenzene Using 2N2O-Salen as a Ligand in Aqueous Solution
  作者：Ningning Gu、Yashuai Liu、Ping Liu、Xiaowei Ma、Liu Yan、Bin Dai

  DOI：10.1002/cjoc.201500446

  日期：2015.10

  catalyzing the Suzuki‐Miyaura reaction of dibromobenzene and arylboronic acid has been developed by using 2N2O‐salen as a ligand in H2O/EtOH (V:V=4:1) at 100°C. Using this method, the reactions of substrates containing sterically demanding ortho substituents (e.g. dibromobenzene and/or arylboronic acids) proceeded efficiently, with the corresponding terphenyl derivatives being produced in moderate to

  通过使用2N2O-salen作为H 2 O / EtOH（V：V = 4：1）中的配体，开发了一种简单高效的Na 2 PdCl 4催化二溴苯和芳基硼酸的Suzuki-Miyaura反应的催化系统。℃。使用该方法，含有空间上要求的邻位取代基（例如二溴苯和/或芳基硼酸）的底物的反应有效地进行，相应的三联苯衍生物以中等至极好的收率生产。此外，该方法为三联苯化合物的克级合成提供了有趣的功能。
• POLYMERIZABLE COMPOUND HAVING TRIPLE BOND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：JNC CORPORATION

  公开号：US20150376505A1

  公开（公告）日：2015-12-31

  To provide a liquid crystal compound having high polymerization reactivity, a high conversion ratio and high solubility in a liquid crystal composition, a polymerizable composition containing the compound, a liquid crystal composite prepared using the composition, and a liquid crystal display device including the composite. The liquid crystal display device prepared using the polymerizable composition containing the compound represented by formula (1): wherein, in formula (1), P 1 to P 6 are a polymerizable group; S 1 to S 6 are a single bond, alkylene or the like; a1, a3 and a4 are an integer from 0 to 4, a2 is an integer from 1 to 4; ring A 1 to ring A 4 are a divalent group derived from benzene, naphthalene, anthracene, pyrimidine, pyridine or the like; Z 1 to Z 3 are a single bond, alkylene or the like, and at least one of Z 1 , Z 2 and Z 3 is —C≡C—; and b1 is 0 or 1.

  为提供一种具有高聚合反应性、高转化率和高溶解度的液晶化合物，本发明提供了一种含有该化合物的可聚合组分、使用该组分制备的液晶复合物以及包括该复合物的液晶显示装置。使用式（1）所表示的化合物制备的聚合物化组分，其中，在式（1）中，P1到P6是可聚合基团；S1到S6是单键、烷基或类似物；a1、a3和a4是0至4的整数，a2是1至4的整数；环A1到环A4是由苯、萘、蒽、嘧啶、吡啶或类似物导出的二价基团；Z1到Z3是单键、烷基或类似物，其中至少一个为—C≡C—；b1为0或1。
• POLYMERIZABLE COMPOUND HAVING CONJUGATED BONDS, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：JNC CORPORATION

  公开号：US20140312274A1

  公开（公告）日：2014-10-23

  Subject It is to provide a polymerizable compound having a high polymerization reactivity, a high conversion yield and a high solubility in a liquid crystal composition, a polymerizable composition including this compound, a liquid crystal composite prepared from this polymerizable composition and a liquid crystal display device containing this composite. Means for solving the Subject A compound represented by formula (1), the liquid crystal composition and the liquid crystal display device. In the formula, for example, ring A 1 , ring A 2 and ring A 4 are phenylene or cyclohexylene; Sp 1 and Sp 2 are a single bond or alkylene having 1 to 6 carbons; Z 1 and Z 2 are —CH═CH— or —C≡C—; a is 1, b is 0; and P 1 and P 2 are a polymerizable group.
• POLYMERIZABLE COMPOUND HAVING OXYGEN-CONTAINING FIVE-MEMBERED RING, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：JNC CORPORATION

  公开号：US20150034871A1

  公开（公告）日：2015-02-05

  An object is to provide a polymerizable compound having high polymerization reactivity, a high conversion ratio and high solubility in a liquid crystal composition, a polymerizable composition containing the compound, a liquid crystal composite prepared from the composition, and a liquid crystal display device having the composite. A solution is a polymerizable compound represented by formula (1). In the formula, for example, P 1 and P 2 are —OCO—(CH 3 )C═CH 2 ; S 1 and S 2 are a single bond; ring A 1 , ring A 2 and ring A 3 are 1,4-phenylene; Z 1 , Z 2 and Z 3 are a single bond; two of G is —CH═ or —N═; and a is 0 or 1.