(2S)-1-[(2S)-2-[[(2S)-2-[(3S,4R)-3-hydroxy-4-[[(2S)-3-[(2S)-3-(4-methoxyphenyl)-2-(methylamino)propanoyl]oxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]-5-methylhexanoyl]oxy-3-methylbutanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carboxylic acid 在
N-甲基吗啉 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下,
以
乙腈 为溶剂,
以57%的产率得到tert-butyl N-[(3S,6S,10S,11R,14S,18S,21S)-10-hydroxy-18-[(4-methoxyphenyl)methyl]-19-methyl-3-(2-methylpropyl)-2,5,8,13,17,20-hexaoxo-6,11-di(propan-2-yl)-7,16-dioxa-1,4,12,19-tetrazabicyclo[19.3.0]tetracosan-14-yl]carbamate