[7-(4-methoxyphenyl)-2,4-dimethylquinolin-8-yl]phenylmethanone | 1443679-92-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [7-(4-methoxyphenyl)-2,4-dimethylquinolin-8-yl]phenylmethanone
• 英文别名: [7-(4-Methoxyphenyl)-2,4-dimethylquinolin-8-yl]-phenylmethanone
• CAS: 1443679-92-2
• 化学式: C₂₅H₂₁NO₂
• 分子量: 367.447
• InChiKey: APEDTTXOJAZYPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,6-dimethyl-2-(phenylethynyl)pyridine-3-carbaldehyde 、 4-乙炔基苯甲醚 在 gold(III) chloride 、 silver hexafluoroantimonate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 16.0h， 以70%的产率得到[7-(4-methoxyphenyl)-2,4-dimethylquinolin-8-yl]phenylmethanone
  参考文献：
  名称：

  Gold-Catalyzed Benzannulation of Electronically Rich/Rich and Deficient/Deficient Oxoalkynes with Alkynes

  摘要：

  Two different strategies have been developed to perform the gold-catalyzed benzannulation of both electron-rich pyridine containing oxoalkynes with electron-rich alkynes as well as electron-deficient pyridine containing oxoalkynes with electron-deficient alkynes. The benzannulation between electron-rich oxoalkynes with electron-rich alkynes proceeds in the presence of highly electron-deficient gold catalysts, whereas using catalytic amount of alcohol benzannulation was performed efficiently between electron-deficient oxoalkynes with electron-deficient alkynes.

  DOI：

  10.1055/s-0032-1318454