2,6-dichloro-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranosyl)-9H-purine | 103885-00-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2,6-dichloro-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranosyl)-9H-purine
• CAS: 103885-00-3
• 化学式: C₁₉H₁₅Cl₂FN₄O₅
• 分子量: 469.256
• InChiKey: GTGXSWKWJGIEEW-GNNTXSLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.16
• 重原子数：
  31.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  105.43
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinose 在 4 A molecular sieve 、 氢溴酸 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 40.0h， 生成 2,6-dichloro-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranosyl)-9H-purine
  参考文献：
  名称：

  9-(2-Deoxy-2-fluoro-.beta.-D-arabinofuranosyl)guanine: a metabolically stable cytotoxic analogue of 2'-deoxyguanosine

  摘要：

  The synthesis of 9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)guanine (1b) from 1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranose (2a) and 2,6-dichloropurine in six steps using an enzymatic deamination as the last step is reported. The target compound was found to be stable to purine nucleoside phosphorylase cleavage and was cytotoxic in two cell lines, one a T-cell line. Incubation of L1210 cells with 1b results in an inhibition of DNA synthesis as judged by the reduced incorporation of labeled thymidine into DNA, while RNA and protein syntheses were unaffected.

  DOI：

  10.1021/jm00161a041