(3-aminopyridin-4-yl)(3-chlorophenyl)methanone | 1258538-83-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3-aminopyridin-4-yl)(3-chlorophenyl)methanone
• 英文别名: (3-Aminopyridin-4-yl)-(3-chlorophenyl)methanone
• CAS: 1258538-83-8
• 化学式: C₁₂H₉ClN₂O
• 分子量: 232.669
• InChiKey: WKBJTHIDZZBPJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲酸 、 (3-aminopyridin-4-yl)(3-chlorophenyl)methanone 在 乙酸酐 作用下， 以86%的产率得到N-[4-(3-chlorobenzoyl)pyridin-3-yl]formamide
  参考文献：
  名称：

  Synthesis of 2,4,8-Trisubstituted 1,7-Naphthyridines by the Reaction of 4-(1-Aryl-2-methoxyethenyl)-3-isocyanopyridines with Excess Organolithiums

  摘要：

  AbstractA convenient method for the synthesis of 2,4,8‐trisubstituted 1,7‐naphthyridines 6 by the reaction of (E)‐4‐(1‐aryl‐2‐methoxyethenyl)‐3‐isocyanopyridines 4, which could be easily prepared from commercially available 3‐aminopyridine via aroylation of lithium (4‐lithiopyridin‐3‐yl)pivalamide with N‐methoxy‐N‐methylbenzamides, with excess organolithiums has been developed.

  DOI：

  10.1002/hlca.201000214
• 作为产物：
  描述：

  N-[4-(3-chlorobenzoyl)pyridin-3-yl]-2,2-dimethylpropanamide 在 水 作用下， 以81%的产率得到(3-aminopyridin-4-yl)(3-chlorophenyl)methanone
  参考文献：
  名称：

  Synthesis of 2,4,8-Trisubstituted 1,7-Naphthyridines by the Reaction of 4-(1-Aryl-2-methoxyethenyl)-3-isocyanopyridines with Excess Organolithiums

  摘要：

  AbstractA convenient method for the synthesis of 2,4,8‐trisubstituted 1,7‐naphthyridines 6 by the reaction of (E)‐4‐(1‐aryl‐2‐methoxyethenyl)‐3‐isocyanopyridines 4, which could be easily prepared from commercially available 3‐aminopyridine via aroylation of lithium (4‐lithiopyridin‐3‐yl)pivalamide with N‐methoxy‐N‐methylbenzamides, with excess organolithiums has been developed.

  DOI：

  10.1002/hlca.201000214

文献信息

• Synthesis of 2,4,8-Trisubstituted 1,7-Naphthyridines by the Reaction of 4-(1-Aryl-2-methoxyethenyl)-3-isocyanopyridines with Excess Organolithiums
  作者：Kazuhiro Kobayashi、Taketoshi Kozuki、Shuhei Fukamachi、Hisatoshi Konishi

  DOI：10.1002/hlca.201000214

  日期：2010.10

  AbstractA convenient method for the synthesis of 2,4,8‐trisubstituted 1,7‐naphthyridines 6 by the reaction of (E)‐4‐(1‐aryl‐2‐methoxyethenyl)‐3‐isocyanopyridines 4, which could be easily prepared from commercially available 3‐aminopyridine via aroylation of lithium (4‐lithiopyridin‐3‐yl)pivalamide with N‐methoxy‐N‐methylbenzamides, with excess organolithiums has been developed.