methyl 2-butyl-5-chloro-3-[[4-[[(2S)-2-pyrrol-1-yl-3-thiophen-2-ylpropanoyl]amino]phenyl]methyl]imidazole-4-carboxylate | 148549-90-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 2-butyl-5-chloro-3-[[4-[[(2S)-2-pyrrol-1-yl-3-thiophen-2-ylpropanoyl]amino]phenyl]methyl]imidazole-4-carboxylate
• CAS: 148549-90-0
• 化学式: C₂₇H₂₉ClN₄O₃S
• 分子量: 525.071
• InChiKey: ZZBOCRGKYWXYAB-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  36
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 2-butyl-5-chloro-3-[[4-[[(2S)-2-pyrrol-1-yl-3-thiophen-2-ylpropanoyl]amino]phenyl]methyl]imidazole-4-carboxylate 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 以97%的产率得到2-Butyl-5-chloro-3-[4-(2-pyrrol-1-yl-3-thiophen-2-yl-propionylamino)-benzyl]-3H-imidazole-4-carboxylic acid
  参考文献：
  名称：

  Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists

  摘要：

  A novel series of non-biphenylyltetrazole angiotensin II receptor antagonists which contain a 1H-pyrrol-1-ylacetyl residue in place of the benzoyl residue in EXP 6803 have been developed. The receptor binding activity of several members of this new series was in the 10(-8) M range, which was better than that of EXP 6803. Introduction of a carboxylic acid moiety at the 2-position of the pyrrole ring enhanced the in vitro binding affinity at the receptor by 10-fold. Compounds containing an acetic acid (18) or a propionic acid residue (20) at the 5-position of the imidazole were more potent than the carboxylic acid analogue (24). The binding IC50 of the most potent compound 20 was 22 nM. Compounds 18, 20, and 24 in their best fit conformations were manually overlayed on that of the template conformation of EXP 6803 and EXP 8623, respectively. The synthesis and structure-activity relationship data are described.

  DOI：

  10.1021/jm00064a007
• 作为产物：
  描述：

  3-(2-噻吩基)-DL-丙氨酸 在 4-二甲氨基吡啶 、 sodium acetate 、 三甲基乙酰氯 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 methyl 2-butyl-5-chloro-3-[[4-[[(2S)-2-pyrrol-1-yl-3-thiophen-2-ylpropanoyl]amino]phenyl]methyl]imidazole-4-carboxylate
  参考文献：
  名称：

  Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists

  摘要：

  A novel series of non-biphenylyltetrazole angiotensin II receptor antagonists which contain a 1H-pyrrol-1-ylacetyl residue in place of the benzoyl residue in EXP 6803 have been developed. The receptor binding activity of several members of this new series was in the 10(-8) M range, which was better than that of EXP 6803. Introduction of a carboxylic acid moiety at the 2-position of the pyrrole ring enhanced the in vitro binding affinity at the receptor by 10-fold. Compounds containing an acetic acid (18) or a propionic acid residue (20) at the 5-position of the imidazole were more potent than the carboxylic acid analogue (24). The binding IC50 of the most potent compound 20 was 22 nM. Compounds 18, 20, and 24 in their best fit conformations were manually overlayed on that of the template conformation of EXP 6803 and EXP 8623, respectively. The synthesis and structure-activity relationship data are described.

  DOI：

  10.1021/jm00064a007

文献信息

• Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists
  作者：Ila Sircar、R. Thomas Winters、John Quin、Gina H. Lu、Terry C. Major、Robert L. Panek

  DOI：10.1021/jm00064a007

  日期：1993.6

  A novel series of non-biphenylyltetrazole angiotensin II receptor antagonists which contain a 1H-pyrrol-1-ylacetyl residue in place of the benzoyl residue in EXP 6803 have been developed. The receptor binding activity of several members of this new series was in the 10(-8) M range, which was better than that of EXP 6803. Introduction of a carboxylic acid moiety at the 2-position of the pyrrole ring enhanced the in vitro binding affinity at the receptor by 10-fold. Compounds containing an acetic acid (18) or a propionic acid residue (20) at the 5-position of the imidazole were more potent than the carboxylic acid analogue (24). The binding IC50 of the most potent compound 20 was 22 nM. Compounds 18, 20, and 24 in their best fit conformations were manually overlayed on that of the template conformation of EXP 6803 and EXP 8623, respectively. The synthesis and structure-activity relationship data are described.