2-(2-fluorophenyl)-1-(pyrazin-2-yl)ethanone | 1184387-17-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-fluorophenyl)-1-(pyrazin-2-yl)ethanone
• 英文别名: 2-(2-Fluorophenyl)-1-pyrazin-2-ylethanone
• CAS: 1184387-17-4
• 化学式: C₁₂H₉FN₂O
• 分子量: 216.215
• InChiKey: DBOKAQMGZVJOHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-fluorophenyl)-1-(pyrazin-2-yl)ethanone 在 盐酸羟胺 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 42.0h， 生成 ethyl 2-((2-(2-fluorophenyl)-1-(pyrazin-2-yl)ethyl)amino)-2-oxoacetate
  参考文献：
  名称：

  [EN] SGC STIMULATORS
  [FR] STIMULATEURS DE SGC

  摘要：

  公开号：

  WO2018089330A8
• 作为产物：
  描述：

  邻溴氟苯 、 2-乙酰基吡嗪 在 potassium phosphate 、 palladium diacetate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲苯 为溶剂， 反应 18.0h， 以80%的产率得到2-(2-fluorophenyl)-1-(pyrazin-2-yl)ethanone
  参考文献：
  名称：

  Mild and General Method for the α-Arylation of Heteroaromatic Ketones

  摘要：

  The development of a general and mild method for Pd-catalyzed alpha-arylation of a variety of ketones bearing multiple heteroatoms is described. The ligand to metal ratio and the position of the heteroatoms with respect to the carbonyl moiety significantly impact the efficiency of these transformations. In addition, these conditions were successfully applied to the alpha-arylation of cyclic imines. A detailed investigation of the scope of this methodology, including the effect of the ligand to metal ratio, is discussed.

  DOI：

  10.1021/ol1000318

文献信息

• SGC stimulators
  申请人：Cyclerion Therapeutics, Inc.

  公开号：US11180493B2

  公开（公告）日：2021-11-23

  The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable. Various compounds are disclosed, including those of Formula (I).

  本公开涉及可溶性鸟苷酸环化酶（sGC）的刺激剂、包含它们的药物制剂及其单独或与一种或多种附加制剂组合的用途，用于治疗各种疾病，其中一氧化氮（NO）浓度的增加和/或环磷酸鸟苷（cGMP）浓度的增加可能是可取的。本文公开了多种化合物，包括式（I）化合物。
• SGC STIMULATORS
  申请人：Cyclerion Therapeutics, Inc.

  公开号：US20200071318A1

  公开（公告）日：2020-03-05

  The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable. Various compounds are disclosed, including those of Formula (I).
• sGC STIMULATORS
  申请人：Cyclerion Therapeutics, Inc.

  公开号：US20220017515A1

  公开（公告）日：2022-01-20

  The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable. Various compounds are disclosed, including those of Formula I:
• [EN] SGC STIMULATORS<br/>[FR] STIMULATEURS DE SGC
  申请人：IRONWOOD PHARMACEUTICALS INC

  公开号：WO2018089330A8

  公开（公告）日：2019-03-28
• Mild and General Method for the α-Arylation of Heteroaromatic Ketones
  作者：Lopa V. Desai、Danan T. Ren、Thorsten Rosner

  DOI：10.1021/ol1000318

  日期：2010.3.5

  The development of a general and mild method for Pd-catalyzed alpha-arylation of a variety of ketones bearing multiple heteroatoms is described. The ligand to metal ratio and the position of the heteroatoms with respect to the carbonyl moiety significantly impact the efficiency of these transformations. In addition, these conditions were successfully applied to the alpha-arylation of cyclic imines. A detailed investigation of the scope of this methodology, including the effect of the ligand to metal ratio, is discussed.