Biflavonyl-(6,6'') | 20081-46-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: Biflavonyl-(6,6'')
• 英文别名: 6-(4-Oxo-2-phenyl-chromen-6-yl)-2-phenyl-chromen-4-one；6-(4-oxo-2-phenylchromen-6-yl)-2-phenylchromen-4-one
• CAS: 20081-46-3
• 化学式: C₃₀H₁₈O₄
• 分子量: 442.471
• InChiKey: RFRYEGZKLVLBMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-溴-2-苯基-(4H)-4-苯并吡喃酮 在 bis-triphenylphosphine-palladium(II) chloride 、 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 二甲基亚砜 、 苯 为溶剂， 反应 22.0h， 生成 Biflavonyl-(6,6'')
  参考文献：
  名称：

  Efficient Synthesis of Biflavones Having A Ring-A Ring of Two Flavone Units Using Suzuki Cross-Coupling Reactions

  摘要：

  Biflavones having a A ring-A ring of two flavone units were easily prepared by using Suzuki cross-coupling reaction of borylated flavones with bromoflavones or flavone-5-triflate in good to excellent yields.

  DOI：

  10.3987/com-10-s(e)36

文献信息

• Synthesis of phospholipase A2 inhibitory biflavonoids
  作者：Jianjun Chen、Hyeun Wook Chang、Hyun Pyo Kim、Haeil Park

  DOI：10.1016/j.bmcl.2006.01.117

  日期：2006.5

  A series of C-C biflavones was designed to investigate the relationship between structural array of different flavone-flavone subunit linkage and the inhibitory activity against phospholipase A(2) (PLA(2)). Among six classes of C-C biflavones designed, four classes of C-C biflavones, which have flavone-flavone subunit linkages at A ring-A ring, A ring-B ring, B ring-B ring, and B ring-C ring, were synthesized. The synthetic biflavones exhibited somewhat different inhibitory activities against sPLA(2)-IIA. Among them, the biflavone a having a C-C 4'-4' linkage showed comparable inhibitory activity with that of the natural biflavonoid, ochnaflavone, and 7-fold stronger activity than that of amentoflavone. Further chemical modification is being carried out in order to obtain the chemically optimized biflavonoids. (C) 2006 Elsevier Ltd. All rights reserved.
• Efficient Synthesis of Biflavones Having A Ring-A Ring of Two Flavone Units Using Suzuki Cross-Coupling Reactions
  作者：Hiroto Nakano、Yukio Hoshino、Haruo Matsuyama、Yoshihito Kohari

  DOI：10.3987/com-10-s(e)36

  日期：——

  Biflavones having a A ring-A ring of two flavone units were easily prepared by using Suzuki cross-coupling reaction of borylated flavones with bromoflavones or flavone-5-triflate in good to excellent yields.