N,N-Diisopropyl-3-benzoyl-4-pyridinecarboxamide | 88329-47-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N,N-Diisopropyl-3-benzoyl-4-pyridinecarboxamide
• 英文别名: 3-Benzoyl-N,N-di(propan-2-yl)pyridine-4-carboxamide
• CAS: 88329-47-9
• 化学式: C₁₉H₂₂N₂O₂
• 分子量: 310.396
• InChiKey: SHRCLRXMGIWIHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  50.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-Diisopropyl-3-benzoyl-4-pyridinecarboxamide 在 氢氧化钾 、 一水合肼 作用下， 以 二乙二醇 为溶剂， 反应 3.75h， 生成 2-ethyl-4-phenylpyrido[3,4-d]pyridazin-1-one
  参考文献：
  名称：

  Application of organolithium and related reagents in synthesis, Part XII. Synthesis of phenyl- and pyridylpyridopyridazinones and their derivatives

  摘要：

  The preparation of the pyridazinones 10a, 10b, 11a, 11b, and 12a, 12b from the ketoamides 7,8, and 9 and hydrazine hydrate is described. It was found that from ketoamides 8b and 9b in addition to the expected pyridopyridazinones 11b and 12b also aminopyridopyridazines 14 and 15 were formed and that ketoamide 7b gave exclusively aminopyridopyridazine 13. The pyridopyridazinones 10b, 11b, and 12b were alkylated with alkyl iodides.

  DOI：

  10.1007/bf00819523
• 作为产物：
  描述：

  N,N-二异丙基异烟酰胺 、 N,N-二甲基苯甲酰胺 在 lithium diisopropyl amide 作用下， 生成 N,N-Diisopropyl-3-benzoyl-4-pyridinecarboxamide
  参考文献：
  名称：

  N，N-二烷基吡啶基羧酰胺在与二异丙基氨基锂反应中的双重行为

  摘要：

  描述了N，N-二异丙基吡啶基羧酸酰胺在与iPr 2 NLi反应中的双重行为，具体取决于给定酰胺的温度和结构。

  DOI：

  10.1016/s0040-4039(00)86243-7

文献信息

• The dual behaviour of N,N-dialkylpyridylcarboxyclic amides in the reaction with lithium diisopropylamide
  作者：Jan Epsztajn、Adam Bieniek、Jacek Z. Brzeziński、Andrzej Jóźwiak

  DOI：10.1016/s0040-4039(00)86243-7

  日期：1983.1

  The dual behaviour of N,N-diisopropylpyridylcarboxylic amides in the reaction with iPr2NLi depending upon temperature and structure of a given amide, is described.

  描述了N，N-二异丙基吡啶基羧酸酰胺在与iPr 2 NLi反应中的双重行为，具体取决于给定酰胺的温度和结构。
• Epsztajn, Jan; Brzezinski, Jacek Z.; Jozwiak, Andrzej, Journal of Chemical Research, Miniprint, 1986, # 1, p. 401 - 441
  作者：Epsztajn, Jan、Brzezinski, Jacek Z.、Jozwiak, Andrzej

  DOI：——

  日期：——
• EPSZTAJN, J.;BIENIEK, A.;BRZEZINSKI, J. Z.;JOZWIAK, A., TETRAHEDRON LETT., 1983, 24, N 43, 4735-4738
  作者：EPSZTAJN, J.、BIENIEK, A.、BRZEZINSKI, J. Z.、JOZWIAK, A.

  DOI：——

  日期：——
• EPSZTAJN, J.;BRZEZINSKI, J. Z.;JOZWIAK, A., J. CHEM. RES. SYNOP., 1986, N 1, 18-19
  作者：EPSZTAJN, J.、BRZEZINSKI, J. Z.、JOZWIAK, A.

  DOI：——

  日期：——
• Application of organolithium and related reagents in synthesis, Part XII. Synthesis of phenyl- and pyridylpyridopyridazinones and their derivatives
  作者：J. Epsztajn、J. Z. Brzeziński、K. Czech

  DOI：10.1007/bf00819523

  日期：1993.5

  The preparation of the pyridazinones 10a, 10b, 11a, 11b, and 12a, 12b from the ketoamides 7,8, and 9 and hydrazine hydrate is described. It was found that from ketoamides 8b and 9b in addition to the expected pyridopyridazinones 11b and 12b also aminopyridopyridazines 14 and 15 were formed and that ketoamide 7b gave exclusively aminopyridopyridazine 13. The pyridopyridazinones 10b, 11b, and 12b were alkylated with alkyl iodides.