4-氨基苯基2,3,6-三-O-乙酰基-4-O-(2,3,4,6-四-O-乙酰基己糖吡喃糖苷)-1-硫代吡喃己糖苷 | 60515-61-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-氨基苯基2,3,6-三-O-乙酰基-4-O-(2,3,4,6-四-O-乙酰基己糖吡喃糖苷)-1-硫代吡喃己糖苷
• 英文名称: Glc2Ac3Ac4Ac6Ac(b1-4)Glc2Ac3Ac6Ac(b)-O-Ph(4-NH2)
• 英文别名: [(2R,3R,4S,5R,6S)-4,5-diacetyloxy-6-(4-aminophenoxy)-3-[(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyoxan-2-yl]methyl acetate
• CAS: 60515-61-9
• 化学式: C₃₂H₄₁NO₁₈
• 分子量: 727.673
• InChiKey: LNDOOFKKBRYBJN-MMXCIQNPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  51
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  247
• 氢给体数：
  1
• 氢受体数：
  19

反应信息

• 作为反应物：
  描述：

  4-氨基苯基2,3,6-三-O-乙酰基-4-O-(2,3,4,6-四-O-乙酰基己糖吡喃糖苷)-1-硫代吡喃己糖苷 、 2,2-联吡啶-5,5-酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 以0.29 g的产率得到
  参考文献：
  名称：

  Hexavalent glycoclusters having tris-bipyridine ferrous complex cores as minimum combinatorial libraries for probing carbohydrate–carbohydrate interactions

  摘要：

  2,2'-Bipyridines having two lactoside- or maltoside-appendages were prepared and then, complexed with ferrous ion to afford the corresponding tris-bipyridine ferrous complexes presenting hexavalent lactoside/maltoside clusters. Each of these complexes provided a simple dynamic combinatorial library composed of two diastereomeric stereoisomers (A and A) whose ratios depend on their relative stabilities. These tris-bipyridine ferrous complexes showed different responses from each other towards alkaline/alkaline-earth metal salts. For example, the lactoside cluster showed unique two-step binding profiles, whereas the maltoside cluster did simple Langmuir-type ones. Our referential experiments revealed that intermolecular lactoside lactoside interactions mediated by the alkaline/alkaline-earth metal cations play essential roles in the two-step binding profiles. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2016.07.026