bis[2-ethoxy-4-(11-oxo-7,8,9,10,11,12-hexahydrobenzo[a]acridin-12-yl)phenyl] succinate | 1159490-18-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: bis[2-ethoxy-4-(11-oxo-7,8,9,10,11,12-hexahydrobenzo[a]acridin-12-yl)phenyl] succinate
• 英文别名: Bis[2-ethoxy-4-(11-oxo-7,8,9,10,11,12-hexahydro-benzo[a]acridin-12-yl)phenyl] succinate；bis[2-ethoxy-4-(11-oxo-8,9,10,12-tetrahydro-7H-benzo[a]acridin-12-yl)phenyl] butanedioate
• CAS: 1159490-18-2
• 化学式: C₅₄H₄₈N₂O₈
• 分子量: 852.984
• InChiKey: WRCOLZOAWXSULU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  64
• 可旋转键数：
  13
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  bis[2-ethoxy-4-(naphthalen-2-yliminomethyl)phenyl] succinate 、 1,3-环己二酮 以 正丁醇 为溶剂， 反应 0.25h， 以52%的产率得到bis[2-ethoxy-4-(11-oxo-7,8,9,10,11,12-hexahydrobenzo[a]acridin-12-yl)phenyl] succinate
  参考文献：
  名称：

  Synthesis of bis[2-methoxy-4-(11-oxo-7,8,9,10,11,12-hexahydrobenzo[a]acridin-12-yl)phenyl] succinates

  摘要：

  Reactions of succinyl chloride with 4-hydroxy-3-methoxybenzaldehyde and 3-ethoxy-4-hydroxybenzaldehyde gave the corresponding succinates which were brought into the condensation with naphthalen-2-amine to obtain Schiff bases. The latter reacted with CH acids (cyclohexane-1,3-dione and 5,5-dimethylcyclohexane-1,3-dione) to form bis[2-alkoxy-4-(11-oxo-7,8,9,10,11,12-hexahydrobenzo[a]acridin-12-yl)phenyl]-succinates which can also be obtained by three-component heterocyclization of naphthalen-2-amine with bis-(2-alkoxy-4-formylphenyl)succinates and CH acid.

  DOI：

  10.1134/s1070428008100175