4-(4'-methoxy-biphenyl-4-yl)-4-oxo-butyric acid methyl ester | 54011-26-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(4'-methoxy-biphenyl-4-yl)-4-oxo-butyric acid methyl ester
• 英文别名: 4-(4'-Methoxy-biphenyl-4-yl)-4-oxo-buttersaeure-methylester；4-(4'-Methoxy-biphenyl-4-yl)4-oxo-butyric acid, methyl ester；methyl 4-[4-(4-methoxyphenyl)phenyl]-4-oxobutanoate
• CAS: 54011-26-6
• 化学式: C₁₈H₁₈O₄
• 分子量: 298.339
• InChiKey: PGZCTHBBQUEDCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(4'-methoxy-biphenyl-4-yl)-4-oxo-butyric acid methyl ester 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 3-(4-p-Methoxyphenylbenzoyl)propionsaeure
  参考文献：
  名称：

  Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases

  摘要：

  描述了联苯丁酸化合物和衍生物，以及用于制备和制备相同的酸方法以及药物组合物，这些组合物可用作基质金属蛋白酶抑制剂，特别是明胶酶A（72kD明胶酶）和基质金属蛋白酶-1的治疗方法，并用于治疗多发性硬化症、动脉粥样硬化斑块破裂、主动脉瘤、心力衰竭、再狭窄、牙周病、角膜溃疡、烧伤治疗、褥疮溃疡、伤口愈合、癌症、炎症、疼痛、关节炎或其他依赖白细胞或其他活化迁移细胞入侵组织的自身免疫或炎症性疾病。

  公开号：

  US20010000513A1
• 作为产物：
  描述：

  4-甲氧基联苯 在 三氯化铝 、 硝基苯 作用下， 生成 4-(4'-methoxy-biphenyl-4-yl)-4-oxo-butyric acid methyl ester
  参考文献：
  名称：

  The Orientation of p-Methoxydiphenyl in the Friedel and Crafts Reaction

  摘要：

  DOI：

  10.1021/ja01300a068

文献信息

• Biphenyl hydroxy imino butyric acids and their derivatives for treating arthritis
  申请人：Warner-Lambert Company

  公开号：US06239288B1

  公开（公告）日：2001-05-29

  Biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of bums, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

  本文描述了联苯基丁酸化合物及其衍生物，以及制备该化合物的酸方法和制药组合物，该化合物可用作基质金属蛋白酶抑制剂，特别是明胶酶A（72 kD明胶酶）和stromelysin-1的抑制剂，用于治疗多发性硬化症、动脉粥样硬化斑块破裂、主动脉瘤、心力衰竭、再狭窄、牙周病、角膜溃疡、烧伤、褥疮、伤口愈合、癌症、炎症、关节炎或其他依赖于白细胞或其他激活迁移细胞侵袭组织的自身免疫或炎症性疾病，以及急性和慢性神经退行性疾病，包括中风、头部创伤、脊髓损伤、阿尔茨海默病、肌萎缩性侧索硬化、脑淀粉样血管病、艾滋病、帕金森病、亨廷顿病、朊病、重症肌无力和杜兴氏肌萎缩症。
• The Orientation of p-Methoxydiphenyl in the Friedel and Crafts Reaction
  作者：L. F. Fieser、Charles K. Bradsher

  DOI：10.1021/ja01300a068

  日期：1936.9
• Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
  申请人：——

  公开号：US20010000513A1

  公开（公告）日：2001-04-26

  Biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells.

  描述了联苯丁酸化合物和衍生物，以及用于制备和制备相同的酸方法以及药物组合物，这些组合物可用作基质金属蛋白酶抑制剂，特别是明胶酶A（72kD明胶酶）和基质金属蛋白酶-1的治疗方法，并用于治疗多发性硬化症、动脉粥样硬化斑块破裂、主动脉瘤、心力衰竭、再狭窄、牙周病、角膜溃疡、烧伤治疗、褥疮溃疡、伤口愈合、癌症、炎症、疼痛、关节炎或其他依赖白细胞或其他活化迁移细胞入侵组织的自身免疫或炎症性疾病。