Dimethyl 5'-cyclohexylimino-11-oxospiro[benzo[b]acridine-6,2'-furan]-3',4'-dicarboxylate | 1384933-86-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Dimethyl 5'-cyclohexylimino-11-oxospiro[benzo[b]acridine-6,2'-furan]-3',4'-dicarboxylate
• CAS: 1384933-86-1
• 化学式: C₃₀H₂₆N₂O₆
• 分子量: 510.546
• InChiKey: ICFLFWBTUVSTRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  38
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-氨基苄胺 在 溶剂黄146 作用下， 以 乙腈 为溶剂， 反应 28.0h， 生成 Dimethyl 5'-cyclohexylimino-11-oxospiro[benzo[b]acridine-6,2'-furan]-3',4'-dicarboxylate
  参考文献：
  名称：

  An unexpected route toward the synthesis of spiro-benzo[b]acridine-furan derivatives

  摘要：

  A facile and straightforward procedure for the synthesis of spiro-benzo[b]acridine-6,2'-furan derivatives via the reaction between benzo[b]acridine-6,11-dione, electron-deficient acetylenic compounds, and an isocyanide is described. The benzo[b]acridine-6,11-dione is obtained from the reaction between 2-(aminomethyl)aniline and 2-hydroxynaphthalene-1,4-dione via an unexpected reaction pathway. The products are synthesized in medium to high yields and no complicated purification is required. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.05.107