[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-nitrophenoxy)oxan-2-yl]methyl benzoate | 337356-42-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-nitrophenoxy)oxan-2-yl]methyl benzoate
• CAS: 337356-42-0
• 化学式: C₁₉H₁₉NO₉
• 分子量: 405.361
• InChiKey: ROYIHGRXGWUTTC-DIKXUDHVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  151
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  [(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-nitrophenoxy)oxan-2-yl]methyl benzoate 在 甲醇 、 N-碘代丁二酰亚胺 、 三氟甲磺酸 、 3 A molecular sieve 、 sodium methylate 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans -sialidase towards NeuAc-α-2,3-Gal-β- O -PNP

  摘要：

  NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were apparent. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00611-9
• 作为产物：
  描述：

  苯甲酰腈 、 4-硝基苯基-D-吡喃葡糖苷 以65%的产率得到[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-nitrophenoxy)oxan-2-yl]methyl benzoate
  参考文献：
  名称：

  Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans -sialidase towards NeuAc-α-2,3-Gal-β- O -PNP

  摘要：

  NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were apparent. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00611-9

文献信息

• Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans -sialidase towards NeuAc-α-2,3-Gal-β- O -PNP
  作者：Jennifer A Harrison、K.P.Ravindranathan Kartha、W.Bruce Turnbull、Shona L Scheuerl、James H Naismith、Sergio Schenkman、Robert A Field

  DOI：10.1016/s0960-894x(00)00611-9

  日期：2001.1

  NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were apparent. (C) 2001 Elsevier Science Ltd. All rights reserved.