N-[(2R,4aR,6S,7R,8R,8aS)-6-((2S,3S,4R,5R,6S)-3,5-Bis-benzyloxy-2-methoxy-6-methyl-tetrahydro-pyran-4-yloxy)-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide | 184048-02-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[(2R,4aR,6S,7R,8R,8aS)-6-((2S,3S,4R,5R,6S)-3,5-Bis-benzyloxy-2-methoxy-6-methyl-tetrahydro-pyran-4-yloxy)-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide
• CAS: 184048-02-0
• 化学式: C₃₆H₄₃NO₁₀
• 分子量: 649.738
• InChiKey: DPHVKLIPPOSPLN-NDUVKUICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.64
• 重原子数：
  47.0
• 可旋转键数：
  11.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  123.17
• 氢给体数：
  2.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  三氧化硫吡啶 、 N-[(2R,4aR,6S,7R,8R,8aS)-6-((2S,3S,4R,5R,6S)-3,5-Bis-benzyloxy-2-methoxy-6-methyl-tetrahydro-pyran-4-yloxy)-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Chemical Synthesis of (3-SO₃Na)GlcNAcβ1→3Fucβ1→OMe: The Oligosaccharide Involved in the Cell Aggregation of the SpongeMicrociona Prolifera

  摘要：

  The methyl glycoside, (3-SO3Na)GlcNAc beta 1-->3Fuc beta 1-->OMe, of a sulfated disaccharide that is involved in the species-specific reaggregation of dissociated cells of Microciona prolifera, was stereoselectively synthesized starting from L-fucose and 2-amino-2-deoxy-D-glucose.

  DOI：

  10.1080/07328309608005702
• 作为产物：
  描述：

  Methyl 2,4-di-O-benzyl-3-O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)-β-L-fucopyranoside 在 吡啶 、 camphor-10-sulfonic acid 、 一水合肼 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.0h， 生成 N-[(2R,4aR,6S,7R,8R,8aS)-6-((2S,3S,4R,5R,6S)-3,5-Bis-benzyloxy-2-methoxy-6-methyl-tetrahydro-pyran-4-yloxy)-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide
  参考文献：
  名称：

  Chemical Synthesis of (3-SO₃Na)GlcNAcβ1→3Fucβ1→OMe: The Oligosaccharide Involved in the Cell Aggregation of the SpongeMicrociona Prolifera

  摘要：

  The methyl glycoside, (3-SO3Na)GlcNAc beta 1-->3Fuc beta 1-->OMe, of a sulfated disaccharide that is involved in the species-specific reaggregation of dissociated cells of Microciona prolifera, was stereoselectively synthesized starting from L-fucose and 2-amino-2-deoxy-D-glucose.

  DOI：

  10.1080/07328309608005702