(2-furoyl)(2-thienoyl)methane | 32267-05-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-furoyl)(2-thienoyl)methane
• 英文别名: 1-furan-2-yl-3-thiophen-2-yl-propane-1,3-dione；1-[2]Furyl-3-[2]thienyl-propan-1,3-dion；1-(Furan-2-yl)-3-(thiophen-2-yl)propane-1,3-dione；1-(furan-2-yl)-3-thiophen-2-ylpropane-1,3-dione
• CAS: 32267-05-3
• 化学式: C₁₁H₈O₃S
• 分子量: 220.249
• InChiKey: AUIPQBDMCXMCDU-UHFFFAOYSA-N

物化性质

• 熔点：
  54.5-55.5 °C
• 沸点：
  192-195 °C(Press: 6 Torr)
• 密度：
  1.301±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  75.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-furoyl)(2-thienoyl)methane 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 生成 5-(furan-2-yl)-3-(thiophen-2-yl)isoxazole
  参考文献：
  名称：

  一些呋喃基取代的β-二酮烯醇化方向的研究

  摘要：

  DOI：

  10.1007/bf00471382
• 作为产物：
  描述：

  2-乙酰基噻吩 在 乙醚 、 sodium amide 作用下， 生成 (2-furoyl)(2-thienoyl)methane
  参考文献：
  名称：

  The Synthesis of Certain β-Diketones Containing a Furan Nucleus

  摘要：

  DOI：

  10.1021/ja01171a512

文献信息

• Iron-Promoted C–C Bond Cleavage of 1,3-Diketones: A Route to 1,2-Diketones under Mild Reaction Conditions
  作者：Lehao Huang、Kai Cheng、Bangben Yao、Yongju Xie、Yuhong Zhang

  DOI：10.1021/jo200840y

  日期：2011.7.15

  A conceptual method for the preparation of 1,2-diketones is reported. The selective C–C bond cleavage of 1,3-diketones affords the 1,2-diketones in high yields under mild reaction conditions in air by the use of FeCl3 as the catalyst and tert-butyl nitrite (TBN) as the oxidant without the use of solvent. The possible reaction mechanism is discussed. This protocol provides an expeditious route to the

  报告了一种制备1,2-二酮的概念方法。通过使用FeCl 3作为催化剂和使用亚硝酸叔丁酯（TBN）作为氧化剂，在温和的反应条件下，在空气中温和的反应条件下，1,3-二酮的选择性C-C键裂解可高产率地提供1,2-二酮使用溶剂。讨论了可能的反应机理。该协议为获得有用的1,2-二酮提供了一条快捷途径。
• Protein particles for therapeutic and diagnostic use
  申请人：——

  公开号：US20020142046A1

  公开（公告）日：2002-10-03

  Albumin particles in the nanometer and micrometer size range in an aqueous suspension are rendered stable against resolubilization without the aid of a cross-linking agent and witout denaturation, by the incorporation of a stabilizing agent in the particle composition. Stabilizing agents disclosed include reducing agents, oxdizing agents, hydrogen-accepting molecules, high molecular weight polymers, and sulfur-containing ring compounds. Also disclosed are fibrinogen-coated particles, cross-linked or non-cross-linked, and their use as co-aggregants with platelets and with themselves for purposes of shortening bleeding time and enhancing the effect of thrombin.

  通过在颗粒组合物中加入稳定剂，可使水悬浮液中纳米和微米大小的白蛋白颗粒在不借助交联剂和不发生变性的情况下稳定地防止溶解。已公开的稳定剂包括还原剂、氧化剂、氢接受分子、高分子量聚合物和含硫环化合物。此外，还公开了交联或非交联的纤维蛋白原涂层微粒，以及它们作为与血小板和自身的共聚物的用途，以达到缩短出血时间和增强凝血酶效果的目的。
• Maize yellow stripe1 and related genes
  申请人：——

  公开号：US20040172670A1

  公开（公告）日：2004-09-02

  The maize yellow stripe1 gene encodes a transmembrane protein which mediates the uptake of chelated iron from soil. The gene is shown here to be upregulated, and protein production increased, under conditions of low iron bioavailability. The protein is also shown to be able to transport other metals as well, such as copper. The present invention also provides a family of Arabidopsis genes and gene products related to ys1 termed here as ys11-8. The invention provides the genes and their gene products as well as methods to create and use transgenic plants for the increased uptake of iron in nutritional crops as well as for the bioremediation of soil.

  玉米黄条纹1基因编码一种跨膜蛋白，它能介导土壤中螯合铁的吸收。研究表明，在铁的生物利用率较低的条件下，该基因会上调，蛋白质的产量也会增加。该蛋白还能转运其他金属，如铜。本发明还提供了与 ys1 相关的拟南芥基因和基因产物家族，在此称为 ys11-8。本发明提供了这些基因及其基因产物，以及创建和使用转基因植物的方法，以增加营养作物对铁的吸收，并对土壤进行生物修复。
• Steady state and laser photolysis studies of keto-enol tautomerizations in 2-alkyl-1,3-diketones having five-membered rings in acetonitrile: Temporal UV-A sunscreen
  作者：Yurie Suwa、Minoru Yamaji

  DOI：10.1016/j.jphotochem.2015.10.010

  日期：2016.2

  Keto-enol tautomerization in 2-alkyl-1,3-diketons having five-membered rings was studied using steady state and laser flash photolysis techniques in solution. The alkyl keto-diketones undergo photoinduced tautomerization mainly in the triplet state to the enol in acetonitrile. The alkyl enol-diketones, thus formed, undergo thermal tautomerization to the original keto forms in a few days. The alkyl enol-diketones show fast internal conversion from the excited singlet state to the ground state without yielding the corresponding isomeric forms (rotamer). Based on the computation for state energies of the keto, enol and isomer forms, a schematic energy diagram for the tautomerization was drawn. (C) 2015 Elsevier B.V. All rights reserved.
• LESYAK T.; NELEK S., XIMIYA GETEROTSIKL. SOEDIN. <KGSS-AQ>, 1975, HO 2, 162-166
  作者：LESYAK T.、 NELEK S.

  DOI：——

  日期：——