4,9-dihydro-pyrano[3,4-b]indole-1,3-dione | 60442-29-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4,9-dihydro-pyrano[3,4-b]indole-1,3-dione
• 英文别名: 4,9-Dihydro-pyrano[3,4-b]indol-1,3-dion；4,9-Dihydropyrano[3,4-b]indole-1,3-dione
• CAS: 60442-29-7
• 化学式: C₁₁H₇NO₃
• mdl: MFCD03828555
• 分子量: 201.181
• InChiKey: DRBDVHIEYHBCGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  59.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,9-dihydro-pyrano[3,4-b]indole-1,3-dione 在 硫酸 、 丙酮 、 苯 作用下， 生成 3-(benzylcarbamoyl-methyl)-indole-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Onda; Sasamoto, Pharmaceutical Bulletin, 1957, vol. 5, p. 305,309

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙酸酐 、 乙酰氯 作用下， 生成 4,9-dihydro-pyrano[3,4-b]indole-1,3-dione
  参考文献：
  名称：

  Kermack; Perkin; Robinson, Journal of the Chemical Society, 1921, vol. 119, p. 1612

  摘要：

  DOI：

文献信息

• IDO Inhibitors
  申请人：Mautino Mario

  公开号：US20110053941A1

  公开（公告）日：2011-03-03

  Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunosuppression associated with an infectious disease, e.g., HIV-I infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein.

  目前提供以下方法：(a) 通过接触本文中描述的化合物的调节有效量与吲哚胺2,3-二氧化酶相互作用，从而调节吲哚胺2,3-二氧化酶的活性；(b) 治疗需要吲哚胺2,3-二氧化酶(IDO)介导的免疫抑制的患者，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(c) 治疗需要抑制吲哚胺-2,3-二氧化酶酶活性的医疗状况，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(d) 增强抗癌治疗的有效性，包括给予抗癌剂和本文中描述的化合物；(e) 治疗与癌症相关的肿瘤特异性免疫抑制，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(f) 治疗与传染病相关的免疫抑制，例如HIV-1感染，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量。
• Cegla; Boksa; Chojnacka-Wojcik, Pharmazie, 1996, vol. 51, # 12, p. 932 - 936
  作者：Cegla、Boksa、Chojnacka-Wojcik、Misztal

  DOI：——

  日期：——
• STANOEVA, ELENA;HAIMOVA, MARIETTA;MOLLOVA, NEVENA;POPOV, SIMEON, GOD. SOFIJSK. UNIV. XIM. FAK., 79,(1985(1990)) S. 458-465
  作者：STANOEVA, ELENA、HAIMOVA, MARIETTA、MOLLOVA, NEVENA、POPOV, SIMEON

  DOI：——

  日期：——
• MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS
  申请人：NeuroSearch A/S

  公开号：EP2139855A1

  公开（公告）日：2010-01-06
• [EN] MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS<br/>[FR] MÉDICAMENTS UTILES EN TANT QUE MODULATEURS DES CANAUX DE POTASSIUM
  申请人：NEUROSEARCH AS

  公开号：WO2008113747A1

  公开（公告）日：2008-09-25

  [EN] This invention relates to pharmaceutical compositions comprising phenylcarbamoyl-methyl-indole derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.
  [FR] La présente invention concerne des compositions pharmaceutiques contenant des dérivés de phénylcarbamoyl-méthyl-indole qui se trouvent être de puissants modulateurs des canaux de potassium et, en tant que tels, sont des candidats intéressants pour le traitement des divers troubles et maladies qui réagissent à la modulation des canaux de potassium.