7-methyl-3-oxo-1,2,6,7-tetrahydrospiro[pyrido-(3,2,1-ij)quinoline-5,1'-cyclohexane] | 487011-18-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-methyl-3-oxo-1,2,6,7-tetrahydrospiro[pyrido-(3,2,1-ij)quinoline-5,1'-cyclohexane]
• 英文别名: 10-Methylspiro[1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8-triene-12,1'-cyclohexane]-2-one
• CAS: 487011-18-7
• 化学式: C₁₈H₂₃NO
• 分子量: 269.387
• InChiKey: XCUPEUCRTVVTNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-methyl-3-oxo-1,2,6,7-tetrahydrospiro[pyrido-(3,2,1-ij)quinoline-5,1'-cyclohexane] 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 7-methyl-1,2,6,7-tetrahydrospiro[pyrido-(3,2,1-ij)quinoline-5,1'-cyclohexane]
  参考文献：
  名称：

  Studies directed to the synthesis of new C-5 spiroannulated julolidines

  摘要：

  Two series of new 7,9-disubstituted spirojulolidines 8a-d and 10a-e were synthesized by acid catalyzed intramolecular cyclization of N-(3-chloropropanoyl) spirodihydroquinolines 5a-d and N-carbethoxymethyl spirodihydroquinolines 7a-e using AlCl3 and PPA, respectively. The spectroscopic analyses of intermediate compounds and the final spirojulolidines were discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)01095-5
• 作为产物：
  描述：

  N-(3-chloropropanoyl)-3,4-dihydro-4-methylspiro[quinoline-2,1'-cyclohexane] 在 三氯化铝 作用下， 以 正庚烷 为溶剂， 反应 1.5h， 以61%的产率得到7-methyl-3-oxo-1,2,6,7-tetrahydrospiro[pyrido-(3,2,1-ij)quinoline-5,1'-cyclohexane]
  参考文献：
  名称：

  Studies directed to the synthesis of new C-5 spiroannulated julolidines

  摘要：

  Two series of new 7,9-disubstituted spirojulolidines 8a-d and 10a-e were synthesized by acid catalyzed intramolecular cyclization of N-(3-chloropropanoyl) spirodihydroquinolines 5a-d and N-carbethoxymethyl spirodihydroquinolines 7a-e using AlCl3 and PPA, respectively. The spectroscopic analyses of intermediate compounds and the final spirojulolidines were discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)01095-5