2-methyl-3t-(4-amino-phenyl)-acrylic acid | 104274-28-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-methyl-3t-(4-amino-phenyl)-acrylic acid
• 英文别名: 2-Methyl-3t-(4-amino-phenyl)-acrylsaeure；p-amino-α-methylcinnamic acid；(E)-3-(4-aminophenyl)-2-methylprop-2-enoic acid
• CAS: 104274-28-4
• 化学式: C₁₀H₁₁NO₂
• 分子量: 177.203
• InChiKey: MUYUDVPKJZCBOA-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methyl-3t-(4-amino-phenyl)-acrylic acid 生成 2-methyl-3t-(4-benzamino-phenyl)-acrylic acid
  参考文献：
  名称：

  The Catalytic Reduction of Nitrocinnamic Acids and Esters

  摘要：

  DOI：

  10.1021/ja01237a006
• 作为产物：
  描述：

  (E)-2-methyl-3-(4-nitrophenyl)acrylic acid 在 乙醇 、 镍 作用下， 生成 2-methyl-3t-(4-amino-phenyl)-acrylic acid
  参考文献：
  名称：

  The Catalytic Reduction of Nitrocinnamic Acids and Esters

  摘要：

  DOI：

  10.1021/ja01237a006

文献信息

• BIS(TRIMETHYLSILYL)PHENYL COMPOUND OR SALT THEREOF, AND USE THEREOF
  申请人：Suda Yoshimitsu

  公开号：US20100210591A1

  公开（公告）日：2010-08-19

  The present invention provides a compound that exhibits an excellent antitumor effect and reduces side effects, such as skin disorders, of the existing retinoid by selectively activating on the nuclear receptor RARα, thereby possibly producing significant improvement of clinical profits. Specifically, the present invention provides a bis(trimethylsilyl)phenyl compound represented by Formula (I): wherein X is N or CH; Y is O or S; R1, R2, and R3 are the same or different and are hydrogen or lower alkyl; R4 and R5 are the same or different and are hydrogen, lower alkyl, or halogen; and a bond between a carbon atom to which R1 is attached and a carbon atom to which R2 is attached is a single bond or a double bond; or a salt thereof.

  本发明提供了一种化合物，该化合物通过选择性激活核受体RARα，展现出优异的抗肿瘤效果并减少现有维甲酸类药物的副作用，如皮肤疾病，从而可能显著提高临床效益。具体而言，本发明提供了一种由式（I）表示的双（三甲基硅基）苯基化合物：其中X是N或CH；Y是O或S；R1、R2和R3相同或不同，是氢或低碳基；R4和R5相同或不同，是氢、低碳基或卤素；以及连接R1和R2所连接的碳原子之间的键是单键或双键；或其盐。
• ALBICIDIN DERIVATIVES, THEIR USE AND SYNTHESIS
  申请人：TECHNISCHE UNIVERSITÄT BERLIN

  公开号：US20150376120A1

  公开（公告）日：2015-12-31

  Antibiotically active compounds characterized by general formula (I), wherein X1, BB, BC, BD, BE and X2 are building blocks with D1, D2, D3, D4 or D5 being linkers which include carbon, sulphur, nitrogen, phosphor and/or oxygen atoms and which are covalently connecting the moities BA and BB, BB and BC, BC and BD, BD and BE and BE and BF, respectively, and wherein in particular the building block BC comprises an amino acid derivative. The compounds for use in a method of treatment of diseases, in particular for use in a method of treatment of bacterial infections are also disclosed.

  具有一般式（I）的抗生素活性化合物的特征，其中X1、BB、BC、BD、BE和X2是具有D1、D2、D3、D4或D5连接器的构建块，包括碳、硫、氮、磷和/或氧原子，并且共价连接BA和BB、BB和BC、BC和BD、BD和BE以及BE和BF的基团，其中特别是构建块BC包括一种氨基酸衍生物。该化合物用于治疗疾病的方法，特别是用于治疗细菌感染的方法。
• Triterpenyl esters of organic acids, process for their production, and hypolipidemic agents composed of them
  申请人：AMANO PHARMACEUTICAL CO., LTD.

  公开号：EP0166542A2

  公开（公告）日：1986-01-02

  A triterpenyl ester of organic acid other than triterpenyl esters of ferulic acid and of monobasic and dibasic saturated fatty acids. A process for producing a triterpenyl ester of organic acid other than esters of ferulic acid and of monobasic and dibasic saturated fatty acids, which comprises the reaction of a triterpenyl alcohol with an acid halide of the corresponding organic acid. A pharmaceutical composition for treatment of hyperlipidemia comprising a pharmaceutical carrier and an effective amount of a triterpenyl ester of organic acid other than triterpenyl esters of dibasic saturated fatty acids. A pharmaceutical composition for treating hyperlipidemia which comprises a pharmaceutical carrier and an effective amount of cyclobranol as an active ingredient.

  一种除阿魏酸三萜酯和单盐基及二盐基饱和脂肪酸三萜酯以外的有机酸三萜酯。一种除阿魏酸酯、单基和二基饱和脂肪酸酯以外的有机酸三萜酯的生产工艺，包括三萜醇与相应有机酸的酸卤化物反应。一种治疗高脂血症的药物组合物，包括药物载体和有效量的有机酸三萜酯（二元饱和脂肪酸三萜酯除外）。一种治疗高脂血症的药物组合物，它包括一种药物载体和有效量的作为活性成 分的环烷醇。
• CURED FILM FORMATION COMPOSITION, ORIENTATION MATERIAL, AND PHASE DIFFERENCE MATERIAL
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2767562A1

  公开（公告）日：2014-08-20

  There is provided a cured-film formation composition that forms a cured film having excellent photoreaction efficiency and solvent resistance, and high adhesion, an orientation material for photo-alignment, and a retardation material formed with the orientation material. The cured-film formation composition comprises a component (A) that is a compound having a photo-aligning group and one substituent selected from a hydroxy group, a carboxy group, and an amino group; a component (B) that is a hydrophilic polymer having one or more substituents selected from a hydroxy group, a carboxy group, and an amino group; and a component (C) that is a cross-linking agent that reacts with the component (A) and the component (B) and reacts at a temperature lower than a sublimation temperature of the component (A), wherein when the component (B) is an acrylic polymer, the cured-film formation composition further comprises a component (E) that is an adhesion enhancing component. The cross-linking agent of the component (C) may be more hydrophilic than the component (A). The orientation material is formed by forming a cured film with the cured-film formation composition and utilizing photo-alignment technique. The retardation material is obtained by applying a polymerizable liquid crystal on the orientation material and curing it.

  本发明提供了一种固化成膜组合物，该组合物可形成具有优异光反应效率和耐溶剂性以及高附着力的固化膜，还提供了一种用于光配位的配向材料，以及一种与配向材料形成的延缓材料。固化成膜组合物包括：组分（A），即具有光配位基团和一个选自羟基、羧基和氨基的取代基的化合物；组分（B），即具有一个或多个选自羟基、羧基和氨基的取代基的亲水性聚合物；和一种成分（C），它是一种交联剂，可与成分（A）和成分（B）反应，反应温度低于成分（A）的升华温度，其中当成分（B）是丙烯酸聚合物时，固化成膜组合物还包括一种成分（E），它是一种附着力增强成分。组分（C）的交联剂可能比组分（A）更亲水。定向材料是通过使用固化成膜组合物形成固化膜并利用光对准技术形成的。将可聚合液晶涂抹在取向材料上并使其固化，即可获得缓凝材料。
• Albicidin derivatives, their use and synthesis
  申请人：TECHNISCHE UNIVERSITAET BERLIN

  公开号：US10308595B2

  公开（公告）日：2019-06-04

  Antibiotically active compounds characterized by general formula (I), wherein X1, BB, BC, BD, BE and X2 are building blocks with D1, D2, D3, D4 or D5 being linkers which include carbon, sulphur, nitrogen, phosphor and/or oxygen atoms and which are covalently connecting the moities BA and BB, BB and BC, BC and BD, BD and BE and BE and BF, respectively, and wherein in particular the building block BC comprises an amino acid derivative. The compounds for use in a method of treatment of diseases, in particular for use in a method of treatment of bacterial infections are also disclosed.

  抗生素活性化合物，其特征为通式(I)，其中X1、BB、BC、BD、BE和X2为结构单元，D1、D2、D3、D4或D5为连接体，包括碳原子、硫原子、氮原子、磷原子和/或氧原子，并分别以共价方式连接摩尔体BA和BB、BB和BC、BC和BD、BD和BE以及BE和BF，其中特别是结构单元BC包括氨基酸衍生物。还公开了用于疾病治疗方法，特别是用于细菌感染治疗方法的化合物。