triethylene glycol hexyl methyl ether | 107265-04-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: triethylene glycol hexyl methyl ether
• 英文别名: Triethylene glycol, hexyl-methyl ether；1-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]hexane
• CAS: 107265-04-3
• 化学式: C₁₃H₂₈O₄
• 分子量: 248.363
• InChiKey: WECDVJWNQLMVAZ-UHFFFAOYSA-N

物化性质

• 沸点：
  304.8±22.0 °C(Predicted)
• 密度：
  0.924±0.06 g/cm3(Predicted)
• 保留指数：
  1660

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  triethylene glycol hexyl methyl ether 、 bis(trifluoromethane)sulfonimide lithium 反应 24.0h， 生成
  参考文献：
  名称：

  Physicochemical Properties of Glyme–Li Salt Complexes as a New Family of Room-temperature Ionic Liquids

  摘要：

  某些甘氨酸-锂盐复合物由甘氨酸和锂盐的等摩尔混合物组成，在常温条件下呈液态，具有高热稳定性、宽电位窗、高离子电导率和高锂离子转移数等理化特性，可被视为室温离子液体的一个新家族。

  DOI：

  10.1246/cl.2010.753
• 作为产物：
  描述：

  三甘醇单甲醚 、 溴己烷 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 18.33h， 以64%的产率得到triethylene glycol hexyl methyl ether
  参考文献：
  名称：

  Physicochemical Properties of Glyme–Li Salt Complexes as a New Family of Room-temperature Ionic Liquids

  摘要：

  某些甘氨酸-锂盐复合物由甘氨酸和锂盐的等摩尔混合物组成，在常温条件下呈液态，具有高热稳定性、宽电位窗、高离子电导率和高锂离子转移数等理化特性，可被视为室温离子液体的一个新家族。

  DOI：

  10.1246/cl.2010.753

文献信息

• MODULATORS OF BTK PROTEOLYSIS AND METHODS OF USE
  申请人：Yale University

  公开号：US20190276459A1

  公开（公告）日：2019-09-12

  The present disclosure relates to bifunctional compounds, which find utility as modulators of Burton's Tyrosine Kinase (BTK). In particular, the present disclosure is directed to bifunctional compounds. One end of a bifunctional compound includes a Von Hippel-Lindau, Cereblon, Inhibitors of Apotosis Proteins, or Mouse Double-Minute Homolog 2 ligand that binds to the respective E3 ubiquitin ligase. The other end of a bifunctional compound includes a moiety that binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. Diseases or disorders that result from aggregation, accumulation, and/or overactivation of the target protein can be treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为Burton的酪氨酸激酶（BTK）的调节剂而有用。特别是，本公开是针对双功能化合物的。双功能化合物的一端包括Von Hippel-Lindau、Cereblon、Inhibitors of Apotosis Proteins或Mouse Double-Minute Homolog 2配体，该配体结合到相应的E3泛素连接酶。双功能化合物的另一端包括结合到目标蛋白质的部分，使目标蛋白质靠近泛素连接酶，以促进目标蛋白质的降解（和抑制）。本公开的化合物和组合物可用于治疗或预防由目标蛋白质的聚集、积累和/或过度活化引起的疾病或障碍。
• FILM, SILICA FILM AND METHOD OF FORMING THE SAME, COMPOSITION FOR FORMING SILICA FILM, AND ELECTRONIC PART
  申请人：Hitachi Chemical Co., Ltd.

  公开号：EP1829945A1

  公开（公告）日：2007-09-05

  The coating film of the invention is obtained by curing an applied film formed by application of a composition containing an organic solvent with a boiling point of 80°C or higher, wherein the shrinkage ratio of the film thickness from the applied film immediately after application is no greater than 27%.

  本发明的涂膜是通过固化由含有沸点为 80°C 或更高的有机溶剂的组合物形成的涂膜而获得的，其中涂膜厚度与涂膜刚涂抹后的收缩率不大于 27%。
• Modulators of BTK proteolysis and methods of use
  申请人：Yale University

  公开号：US11028088B2

  公开（公告）日：2021-06-08

  The present disclosure relates to bifunctional compounds, which find utility as modulators of Burton's Tyrosine Kinase (BTK). In particular, the present disclosure is directed to bifunctional compounds. One end of a bifunctional compound includes a Von Hippel-Lindau, Cereblon, Inhibitors of Apotosis Proteins, or Mouse Double-Minute Homolog 2 ligand that binds to the respective E3 ubiquitin ligase. The other end of a bifunctional compound includes a moiety that binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. Diseases or disorders that result from aggregation, accumulation, and/or overactivation of the target protein can be treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，这些化合物可用作伯顿酪氨酸激酶（BTK）的调节剂。特别是，本公开涉及双功能化合物。双功能化合物的一端包括与相应 E3 泛素连接酶结合的 Von Hippel-Lindau、Cereblon、抑制细胞凋亡蛋白或小鼠双敏同源物 2 配体。双功能化合物的另一端包括与靶蛋白结合的分子，这样靶蛋白就会被置于泛素连接酶附近，以实现对靶蛋白的降解（和抑制）。本公开的化合物和组合物可以治疗或预防由于靶蛋白的聚集、积累和/或过度激活而导致的疾病或失调。
• Film, Silica Film and Method of Forming the Same, Composition for Forming Silica Film, and Electronic Part
  申请人：Sakurai Haruaki

  公开号：US20080260956A1

  公开（公告）日：2008-10-23

  The coating film of the invention is obtained by curing an applied film formed by application of a composition containing an organic solvent with a boiling point of 80° C. or higher, wherein the shrinkage ratio of the film thickness from the applied film immediately after application is no greater than 27%.
• COMPOSITION FOR FORMING N-TYPE DIFFUSION LAYER, METHOD FOR FORMING N-TYPE DIFFUSION LAYER, AND METHOD FOR PRODUCING PHOTOVOLTAIC CELL
  申请人：MACHII YOUICHI

  公开号：US20110195541A1

  公开（公告）日：2011-08-11

  The composition for forming an n-type diffusion layer in accordance with the present invention contains a donor element-containing glass powder and a dispersion medium. An n-type diffusion layer and a photovoltaic cell having an n-type diffusion layer are prepared by applying the composition for forming an n-type diffusion layer, followed by a thermal diffusion treatment.