[(1R)-2-methyl-1-[(4-methylphenyl)sulfonylamino]-1-phenylpropan-2-yl] (R)-2,4,6-tri(propan-2-yl)benzenesulfinate | 1310105-60-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(1R)-2-methyl-1-[(4-methylphenyl)sulfonylamino]-1-phenylpropan-2-yl] (R)-2,4,6-tri(propan-2-yl)benzenesulfinate
• CAS: 1310105-60-2
• 化学式: C₃₂H₄₃NO₄S₂
• 分子量: 569.83
• InChiKey: YNSSKUIPVDEQPC-XWDCEDKXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  39
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  [(1R)-2-methyl-1-[(4-methylphenyl)sulfonylamino]-1-phenylpropan-2-yl] (R)-2,4,6-tri(propan-2-yl)benzenesulfinate 在 lithium amide 、 氨 作用下， 生成 (R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺 、 (R)-(+)-2,4,6-triisopropylphenylsulfinamide
  参考文献：
  名称：

  Enantioselective Synthesis of Diverse Sulfinamides and Sulfinylferrocenes from Phenylglycine-Derived Chiral Sulfinyl Transfer Agent

  摘要：

  A new chiral sulfinyl, transfer auxiliary derived from readily available phenylglycine was developed. This auxiliary is utilized to synthesize a diverse array of alkyl- and arylsulfinamides and sulfinylferrocenes in high yields and excellent ee's. The desired products are produced in a one-pot sequence from the oxathiazolidine 2-oxide by two sequential nucleophilic additions that proceed in a stereospecific manner.

  DOI：

  10.1021/jo200715c
• 作为产物：
  描述：

  (R)-氨基苯乙酸甲酯 在 吡啶 、 氯化亚砜 、 碳酸氢钠 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 生成 [(1R)-2-methyl-1-[(4-methylphenyl)sulfonylamino]-1-phenylpropan-2-yl] (R)-2,4,6-tri(propan-2-yl)benzenesulfinate
  参考文献：
  名称：

  Enantioselective Synthesis of Diverse Sulfinamides and Sulfinylferrocenes from Phenylglycine-Derived Chiral Sulfinyl Transfer Agent

  摘要：

  A new chiral sulfinyl, transfer auxiliary derived from readily available phenylglycine was developed. This auxiliary is utilized to synthesize a diverse array of alkyl- and arylsulfinamides and sulfinylferrocenes in high yields and excellent ee's. The desired products are produced in a one-pot sequence from the oxathiazolidine 2-oxide by two sequential nucleophilic additions that proceed in a stereospecific manner.

  DOI：

  10.1021/jo200715c