15-cinnamoyloxylathr-5E,12E-dien-3,7-diol-14-one | 1436434-27-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 15-cinnamoyloxylathr-5E,12E-dien-3,7-diol-14-one
• CAS: 1436434-27-3
• 化学式: C₂₉H₃₆O₅
• 分子量: 464.602
• InChiKey: RCWGAZSKJHAWNO-HZUKRVTNSA-N

反应信息

• 作为产物：
  描述：

  jolkinol B 在 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以1.2 mg的产率得到euphoractine E
  参考文献：
  名称：

  Diterpenoids with Diverse Skeletons from the Roots of Euphorbia micractina

  摘要：

  Twelve new minor diterpenoids, possessing 5/6/8 (1 and 2), 5/6/7/3 (3-9), and 5/6/6/4 (10-12) fused ring skeletons, as determined by spectroscopic analysis, were isolated from an ethanol extract of the roots of Euphorbia micractina, together with 25 known compounds. The structures of the diterpene skeletons are rare and have been found only M compounds isolated from Euphorbia micractina and Euphorbia villosa. On the basis of the octant rule for cyclohexanones, the absolute configurations of 1-12, as well as of the known euphactins A-D and euphoractins A-D (13-15)) could be assigned by circular dichroism spectroscopy. In addition, the co-occurring jolkinol B (16) was chemically transformed to euphoractin E (17), supporting the absolute configuration assignment and the biogenetic relationship between the different types of diterpenes. Compound 9 showed activity against HIV-1 replication in vitro, with an IC50,value of 8.8 +/- 0.6 mu M.

  DOI：

  10.1021/np400029d