2-phenethoxythiophene | 1071994-82-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-phenethoxythiophene
• 英文别名: 2-(2-Phenylethoxy)thiophene
• CAS: 1071994-82-5
• 化学式: C₁₂H₁₂OS
• 分子量: 204.293
• InChiKey: AHYDHBYIYRCSIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  37.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-phenethoxythiophene 在 溶剂黄146 、 三乙胺 、 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 33.5h， 生成 ethyl ((5-phenethoxythiophen-2-yl)methyl)glycinate
  参考文献：
  名称：

  NOVEL P62 LIGAND COMPOUND, AND COMPOSITION CONTAINING SAME FOR PREVENTING, AMELIORATING, OR TREATING PROTEINOPATHIES

  摘要：

  Novel p62 ligand compounds, or a stereoisomer, a solvate, a hydrate, or a prodrug thereof are disclosed. The novel compounds, stereoisomer, solvate, hydrate, or prodrug activates selective autophagy in cells to selectively remove proteins, organelles, and coagulations in the body, and thus can be advantageously used as a pharmaceutical composition for preventing, ameliorating, or treating various proteinopathies. Compositions such as pharmaceutical composition or food compositions containing the novel p62 ligand compounds, stereoisomer, solvate, hydrate, or prodrug thereof as well as uses thereof are disclosed.

  公开号：

  US20220402873A1
• 作为产物：
  描述：

  2-甲氧基噻吩 、 苯乙醇 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 以0.9 g的产率得到2-phenethoxythiophene
  参考文献：
  名称：

  NOVEL P62 LIGAND COMPOUND, AND COMPOSITION CONTAINING SAME FOR PREVENTING, AMELIORATING, OR TREATING PROTEINOPATHIES

  摘要：

  Novel p62 ligand compounds, or a stereoisomer, a solvate, a hydrate, or a prodrug thereof are disclosed. The novel compounds, stereoisomer, solvate, hydrate, or prodrug activates selective autophagy in cells to selectively remove proteins, organelles, and coagulations in the body, and thus can be advantageously used as a pharmaceutical composition for preventing, ameliorating, or treating various proteinopathies. Compositions such as pharmaceutical composition or food compositions containing the novel p62 ligand compounds, stereoisomer, solvate, hydrate, or prodrug thereof as well as uses thereof are disclosed.

  公开号：

  US20220402873A1

文献信息

• A Comparative Ancillary Ligand Survey in Palladium-Catalyzed C-O Cross-Coupling of Primary and Secondary Aliphatic Alcohols
  作者：Ryan S. Sawatzky、Breanna K. V. Hargreaves、Mark Stradiotto

  DOI：10.1002/ejoc.201600198

  日期：2016.5

  palladium-catalyzed C–O cross-coupling reactions involving aliphatic alcohols and (hetero)aryl halides under analogous conditions was examined, both at room temperature and at elevated temperature (90 °C). In general, the RockPhos-based catalyst system proved superior, especially at room temperature, but catalysts based on the other ligands examined also proved effective across a range of C–O cross-couplings, in some

  研究了 RockPhos、Ad-BippyPhos、JosiPhos (CyPF-tBu) 和 Mor-DalPhos 在钯催化的 C-O 交叉偶联反应中的效用，该反应涉及类似条件下的脂肪醇和（杂）芳基卤化物，均在室温下进行并且在高温 (90 °C) 下。总的来说，基于 RockPhos 的催化剂体系被证明是优越的，尤其是在室温下，但基于其他配体的催化剂也被证明在一系列 C-O 交叉偶联中是有效的，在某些情况下提供比 RockPhos 更好的催化性能。根据室温反应的范围建立了新的反应性。还展示了涉及甲磺酸芳基酯的此类交叉偶联的原理证明示例。
• Facile preparation of thiophene C2-ethers using the Mitsunobu reaction
  作者：Craig S. Harris、Hervé Germain、Georges Pasquet

  DOI：10.1016/j.tetlet.2008.07.153

  日期：2008.10

  The preparation of thiophene ethers generally requires forcing conditions thus limiting the choice of alkyl substituent. Herein, we report the first successful generally applicable conditions for the selective O-alkylation of 2(5H)-thiophenone.

  噻吩醚的制备通常需要强制条件，因此限制了烷基取代基的选择。在这里，我们报道了2（5 H）-噻吩的选择性O-烷基化的第一个成功的普遍适用条件。
• [EN] NOVEL P62 LIGAND COMPOUND, AND COMPOSITION CONTAINING SAME FOR PREVENTING, AMELIORATING, OR TREATING PROTEINOPATHIES<br/>[FR] NOUVEAU COMPOSÉ LIGAND P62 ET COMPOSITION LE CONTENANT POUR PRÉVENIR, ATTÉNUER OU TRAITER DES PROTÉINOPATHIES<br/>[KO] 신규한 p62 리간드 화합물, 이를 포함하는 단백질이상질환의 예방, 개선 또는 치료용 조성물
  申请人：AUTOTAC INC

  公开号：WO2021054804A1

  公开（公告）日：2021-03-25

  본 발명은 신규한 화학식 1의 p62 리간드 화합물, 이의 입체 이성질체, 용매화물, 수화물 또는 프로드럭, 이를 유효성분으로 포함하는 변형단백질환의 예방 또는 치료용 약학적 또는 식품 조성물에 관한 것으로, 본 발명에 따른 p62 리간드 화합물은 세포 내 선택적 오토파지를 활성화하여 체내 단백질, 소기관 및 응고체들을 선택적으로 제거함에 따라 다양한 단백질이상질환의 예방, 개선 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.