ethyl 4-(4-hydroxyphenyl)-2-methyl-5-oxo-5,6,7,8-tetrahydroquinoline-3-carboxylate | 1373710-15-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 4-(4-hydroxyphenyl)-2-methyl-5-oxo-5,6,7,8-tetrahydroquinoline-3-carboxylate
• 英文别名: ethyl 4-(4-hydroxyphenyl)-2-methyl-5-oxo-7,8-dihydro-6H-quinoline-3-carboxylate
• CAS: 1373710-15-6
• 化学式: C₁₉H₁₉NO₄
• 分子量: 325.364
• InChiKey: QQJLVTMNMOTKLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  76.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-methyl-5-oxo-4-(4-hydroxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid ethyl ester 在 graphite oxide 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以94%的产率得到ethyl 4-(4-hydroxyphenyl)-2-methyl-5-oxo-5,6,7,8-tetrahydroquinoline-3-carboxylate
  参考文献：
  名称：

  Graphite oxide mediated oxidative aromatization of 1,4-dihydropyridines into pyridine derivatives

  摘要：

  A new approach utilizing graphite oxide as an oxidizing agent is applied for the oxidative aromatization of 1,4-dihydropyridines. Graphite oxide efficiently aromatized Hantzsch 1,4-dihydropyridines into their corresponding pyridine derivatives in excellent yields. The reaction was carried out in toluene at 100 degrees C. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.03.026