(S)-16-azido-1-(2-(((S)-2-hydroxydodecyl)oxy)ethoxy)hexadecan-2-ol | 1616683-40-9

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: (S)-16-azido-1-(2-(((S)-2-hydroxydodecyl)oxy)ethoxy)hexadecan-2-ol
• CAS: 1616683-40-9
• 化学式: C₃₀H₆₁N₃O₄
• 分子量: 527.832
• InChiKey: QDRLTZHLZSIFJS-KYJUHHDHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.65
• 重原子数：
  37.0
• 可旋转键数：
  31.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  107.68
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (S)-16-azido-1-(2-(((S)-2-hydroxydodecyl)oxy)ethoxy)hexadecan-2-ol 、 1-丙炔-2-哌嗪 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 四氢呋喃 、 水 为溶剂， 以47%的产率得到(S)-1-(2-(((S)-2-hydroxydodecyl)oxy)ethoxy)-16-(4-(piperazin-1-ylmethyl)-1H-1,2,3-triazol-1-yl)hexadecan-2-ol
  参考文献：
  名称：

  New cytotoxic annonaceous acetogenin mimetics having a nitrogen-heterocyclic terminal and their application to cell imaging

  摘要：

  A terminal unsaturated lactone or its equivalent is commonly believed to be essential for the cytotoxicity of natural annonaceous acetogenins and their artificial mimetics. In this work, we discovered a series of new cytotoxic ethylene glycol ether-containing mimetics, in which a variety of simple aliphatic nitrogen-heterocycles were introduced to replace the lactone terminal of AA005 (1), a representative bioactive polyether mimic identified from our previous research, for the first time. Among these, mimic 4 bearing a terminal piperazine was found to be the most potent compound against the proliferation of three cancer cells. Based on our new findings, a fluorescent probe 7 was also developed and successfully applied to the imaging of cancer cells. This work provides a new strategy for developing simpler cytotoxic mimetics of natural annonaceous acetogenins and molecular tools for biological imaging. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.05.047
• 作为产物：
  描述：

  在 盐酸 、 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 正丁基锂 、 sodium azide 、 p-toluenesulfonylhydrazide 、 sodium acetate 、 甲基磺酰氯 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 乙二醇二甲醚 、 正己烷 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.83h， 生成 (S)-16-azido-1-(2-(((S)-2-hydroxydodecyl)oxy)ethoxy)hexadecan-2-ol
  参考文献：
  名称：

  New cytotoxic annonaceous acetogenin mimetics having a nitrogen-heterocyclic terminal and their application to cell imaging

  摘要：

  A terminal unsaturated lactone or its equivalent is commonly believed to be essential for the cytotoxicity of natural annonaceous acetogenins and their artificial mimetics. In this work, we discovered a series of new cytotoxic ethylene glycol ether-containing mimetics, in which a variety of simple aliphatic nitrogen-heterocycles were introduced to replace the lactone terminal of AA005 (1), a representative bioactive polyether mimic identified from our previous research, for the first time. Among these, mimic 4 bearing a terminal piperazine was found to be the most potent compound against the proliferation of three cancer cells. Based on our new findings, a fluorescent probe 7 was also developed and successfully applied to the imaging of cancer cells. This work provides a new strategy for developing simpler cytotoxic mimetics of natural annonaceous acetogenins and molecular tools for biological imaging. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.05.047