(2,6-diamino-3-pyridinyl)(2,6-difluorophenyl)methanone | 852997-62-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2,6-diamino-3-pyridinyl)(2,6-difluorophenyl)methanone
• 英文别名: 3-Acyl-2,6-diaminopyridine deriv. 3a；(2,6-diaminopyridin-3-yl)-(2,6-difluorophenyl)methanone
• CAS: 852997-62-7
• 化学式: C₁₂H₉F₂N₃O
• 分子量: 249.22
• InChiKey: HLBQAUFYAHXRJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2,6-diamino-3-pyridinyl)(2,6-difluorophenyl)methanone 在 tris(dibenzylideneacetone)dipalladium (0) 、 氢气 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 1,4-二氧六环 为溶剂， 生成 [2-amino-6-[(4-aminophenyl)amino]-3-pyridinyl](2,6-difluorophenyl)
  参考文献：
  名称：

  3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation

  摘要：

  A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells. © 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.024
• 作为产物：
  描述：

  2,6-二氟苯甲酰氯 在 氢氧化钾 、 正丁基锂 、 四甲基乙二胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 25.0h， 生成 (2,6-diamino-3-pyridinyl)(2,6-difluorophenyl)methanone
  参考文献：
  名称：

  3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation

  摘要：

  A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells. © 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.024

文献信息

• [EN] AMINO SUBSTITUTED PYRIDINYL METHANONE COMPOUNDS USEFUL IN TREATING KINASE DISORDERS<br/>[FR] COMPOSES DE PYRIDINYL-METHANONE AMINO SUBSTITUES UTILES DANS LE TRAITEMENT DE TROUBLES INDUITS PAR LA KINASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005051387A1

  公开（公告）日：2005-06-09

  The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliorate CDK mediated disorders. The invention thus also provides the therapeutic or prophylactic use of the compounds and/or pharmaceutical compositions to treat such disorders.

  本发明提供了氨基取代的吡啶甲酮化合物；包括这些化合物的药物组合物以及它们的合成方法。这些化合物是细胞周期依赖性激酶（CDK）抑制剂，可用于治疗或缓解CDK介导的疾病。因此，本发明还提供了利用这些化合物和/或药物组合物治疗此类疾病的治疗或预防用途。
• Amino substituted pyridinyl methanone compounds useful in treating kinase disorders
  申请人：Lin Ronghui

  公开号：US20050124610A1

  公开（公告）日：2005-06-09

  The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliorate CDK mediated disorders. The invention thus also provides the therapeutic or prophylactic use of the compounds and/or pharmaceutical compositions to treat such disorders.

  本发明提供了氨基取代的吡啶基甲酮化合物；包括该化合物的药物组合物和其合成方法。这些化合物是细胞周期依赖性激酶（CDK）抑制剂，可用于治疗或改善CDK介导的疾病。因此，本发明还提供了该化合物和/或药物组合物的治疗或预防用于治疗此类疾病的方法。
• US7109220B2
  申请人：——

  公开号：US7109220B2

  公开（公告）日：2006-09-19
• 3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation
  作者：Ronghui Lin、Yanhua Lu、Steven K. Wetter、Peter J. Connolly、Ignatius J. Turchi、William V. Murray、Stuart L. Emanuel、Robert H. Gruninger、Angel R. Fuentes-Pesquera、Mary Adams、Niranjan Pandey、Sandra Moreno-Mazza、Steven A. Middleton、Linda K. Jolliffe

  DOI：10.1016/j.bmcl.2005.03.024

  日期：2005.5

  A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells. © 2005 Elsevier Ltd. All rights reserved.