1-(quinolin-5-yl)ethanol | 880782-86-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(quinolin-5-yl)ethanol
• 英文别名: 1-quinolin-5-ylethanol
• CAS: 880782-86-5
• 化学式: C₁₁H₁₁NO
• 分子量: 173.214
• InChiKey: RRKUEGFYNWVLTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933499090

反应信息

• 作为反应物：
  描述：

  1-(quinolin-5-yl)ethanol 在 氯化亚砜 、 sodium hydroxide 、 碳酸氢钠 作用下， 以 氯仿 、 水 为溶剂， 反应 1.0h， 以76%的产率得到5-(1-chloro-ethyl)-quinoline
  参考文献：
  名称：

  4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists

  摘要：

  Formula 1的化合物，其中变量的含义如规范中所定义的，是alpha2肾上腺素受体的激动剂。本公开的若干化合物是特异性或选择性地作用于alpha2B和/或alpha2C肾上腺素受体，而不是alpha2A肾上腺素受体。此外，一些所述的化合物几乎没有心血管和/或镇静作用，或者仅有极小的作用。Formula 1的化合物在哺乳动物中，包括人类，作为治疗对alpha2肾上腺素受体激动剂有响应的疾病和/或症状缓解的药物是有用的。具有无显著心血管和/或镇静作用的Formula 1的化合物可用于治疗疼痛和其他症状，具有最小的副作用。

  公开号：

  US20060069144A1
• 作为产物：
  描述：

  1-喹啉-5-乙酮 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.2h， 以77%的产率得到1-(quinolin-5-yl)ethanol
  参考文献：
  名称：

  [EN] MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS
  [FR] ANTAGONISTES DES RÉCEPTEURS MUSCARINIQUES DE L'ACÉTYLCHOLINE M1

  摘要：

  本文提供了一些化合物，这些化合物可用作胆碱能乙酰胆碱受体M1（mAChR M1）的拮抗剂；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗与胆碱能乙酰胆碱受体功能障碍相关的神经和精神疾病的方法。

  公开号：

  WO2021071843A1

文献信息

• 4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as α2 adrenergic agonists
  申请人：Allergan, Inc.

  公开号：US07396849B2

  公开（公告）日：2008-07-08

  Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.

  式1的化合物，其中变量的含义在说明书中定义，是α2肾上腺素受体的激动剂。本公开的几种化合物在选择性上特异或选择性地作用于α2B和/或α2C肾上腺素受体，而不是α2A肾上腺素受体。此外，一些所述的化合物没有或只有极小的心血管和/或镇静活性。式1的化合物在哺乳动物中，包括人类，用于治疗对α2肾上腺素受体激动剂有反应的疾病和/或缓解条件中是有用的。没有显著心血管和/或镇静活性的式1的化合物可用于治疗疼痛和其他具有最小副作用的病症。
• 4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
  申请人：Allergan, Inc.

  公开号：US07838545B2

  公开（公告）日：2010-11-23

  Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardiovascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.

  式1的化合物，其中变量具有说明书中定义的含义，是α2肾上腺素受体的激动剂。本公开的几种化合物对α2B和/或alpha2C肾上腺素受体具有特异性或选择性，而优先于alpha2A肾上腺素受体。此外，一些声称的化合物没有或只有最小的心血管和/或镇静活性。式1的化合物在哺乳动物，包括人类中，用于治疗对α2肾上腺素受体激动剂有反应的疾病和/或缓解条件是有用的。具有无显著心血管和/或镇静活性的式1的化合物可用于治疗疼痛和其他具有最小副作用的情况。
• 4-(CONDENSED CYCLICMETHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS
  申请人：Heidelbaugh Todd M.

  公开号：US20090176828A1

  公开（公告）日：2009-07-09

  Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha 2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha 2B and/or alpha 2C adrenergic receptors in preference over alpha 2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardiovascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha 2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.

  式1的化合物，其中变量的含义在规范中定义，是alpha2肾上腺素受体的激动剂。本公开的几种化合物是特异性或选择性地作用于alpha2B和/或alpha2C肾上腺素受体，而不是alpha2A肾上腺素受体。此外，一些所述的化合物没有或只有极小的心血管和/或镇静作用。式1的化合物可用作哺乳动物，包括人类的药物，用于治疗对alpha2肾上腺素受体激动剂有反应的疾病和/或缓解条件。没有明显心血管和/或镇静作用的式1的化合物可用于治疗疼痛和其他具有最小副作用的疾病。
• EP2287173
  申请人：——

  公开号：——

  公开（公告）日：——
• X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases
  作者：Yahira M. Báez-Santos、Scott J. Barraza、Michael W. Wilson、Michael P. Agius、Anna M. Mielech、Nicole M. Davis、Susan C. Baker、Scott D. Larsen、Andrew D. Mesecar

  DOI：10.1021/jm401712t

  日期：2014.3.27

  Structure-guided design was used to generate a series of noncovalent inhibitors with nanomolar potency against the papain-like protease (PLpro) from the SARS coronavirus (CoV). A number of inhibitors exhibit antiviral activity against SARS-CoV infected Vero E6 cells and broadened specificity toward the homologous PLP2 enzyme from the human coronavirus NL63. Selectivity and cytotoxicity studies established a more than 100-fold preference for the coronaviral enzyme over homologous human deubiquitinating enzymes (DUBs), and no significant cytotoxicity in Vero E6 and HEK293 cell lines is observed. X-ray structural analyses of inhibitor-bound crystal structures revealed subtle differences between binding modes of the initial benzodioxolane lead (15g) and the most potent analogues 3k and 3j, featuring a monofluoro substitution at para and meta positions of the benzyl ring, respectively. Finally, the less lipophilic bis(amide) 3e and methoxypyridine 5c exhibit significantly improved metabolic stability and are viable candidates for advancing to in vivo studies.