5-thioacetylpentyl 2-acetamido-2-deoxy-α-D-galactopyranoside | 851870-60-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-thioacetylpentyl 2-acetamido-2-deoxy-α-D-galactopyranoside
• 英文别名: thioacetoxypentyl-2-deoxy-2-acetamido-α-D-galactopyranoside
• CAS: 851870-60-5
• 化学式: C₁₅H₂₇NO₇S
• 分子量: 365.448
• InChiKey: QHIZHWCMTRAMPF-QMIVOQANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  24.0
• 可旋转键数：
  9.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  125.32
• 氢给体数：
  4.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  5-thioacetylpentyl 2-acetamido-2-deoxy-α-D-galactopyranoside 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以89%的产率得到thiopentyl-2-deoxy-2-acetamido-α-D-galactopyranoside
  参考文献：
  名称：

  [EN] CARBOHYDRATE ANTIGEN-NANOPARTICLE CONJUGATES AND USES THEREOF AS ANTIMETASTATIC AGENTS IN TREATING CANCER
  [FR] CONJUGUES DE NANOPARTICULES-ANTIGENES CARBOHYDRATE ET UTILISATION COMME AGENTS ANTI-METASTATIQUES DANS LE TRAITEMENT DU CANCER

  摘要：

  公开号：

  WO2005046722A3
• 作为产物：
  描述：

  thioacetoxypentyl-2-deoxy-4,6-benzylidene-2-acetamido-α-D-galactopyranoside 在 溶剂黄146 作用下， 以 水 为溶剂， 反应 3.0h， 以56%的产率得到5-thioacetylpentyl 2-acetamido-2-deoxy-α-D-galactopyranoside
  参考文献：
  名称：

  [EN] CARBOHYDRATE ANTIGEN-NANOPARTICLE CONJUGATES AND USES THEREOF AS ANTIMETASTATIC AGENTS IN TREATING CANCER
  [FR] CONJUGUES DE NANOPARTICULES-ANTIGENES CARBOHYDRATE ET UTILISATION COMME AGENTS ANTI-METASTATIQUES DANS LE TRAITEMENT DU CANCER

  摘要：

  公开号：

  WO2005046722A3

文献信息

• Preparation of multifunctional glyconanoparticles as a platform for potential carbohydrate-based anticancer vaccines
  作者：Rafael Ojeda、Jose Luis de Paz、Africa G. Barrientos、Manuel Martín-Lomas、Soledad Penadés

  DOI：10.1016/j.carres.2006.11.018

  日期：2007.2

  A novel platform for anticancer vaccines has been prepared using glyconanotechnology recently developed in our laboratory. Ten different multifunctional gold glyconanoparticles incorporating sialylTn and Lewis(y) antigens, T-cell helper peptides (TT) and glucose in well defined average proportions and with differing density have been synthesised in one step and characterised using NMR and TEM. Size and nature of the linker were crucial to control kinetics of S-Au bond formation and to achieve the desired ligand ratio on the gold clusters. The technology presented here opens the way for tailoring polyvalent anticancer vaccines candidates and drug delivery carriers with defined average chemical composition. (c) 2006 Elsevier Ltd. All rights reserved.